Martin S L, Zimmer E A, Davidson W S, Wilson A C, Kan Y W
Cell. 1981 Sep;25(3):737-41. doi: 10.1016/0092-8674(81)90181-1.
We have sequenced the 3' and 5' untranslated regions of beta-globin mRNAs from cebus monkey, rhesus monkey and chimpanzee. A comparison with the corresponding human sequences reveals that the rate of sequence divergence among the higher primates is the same in the 3' and 5' noncoding regions and that this rate is several times lower than the rate for silent substitutions in the coding regions. In addition, the rate of sequence divergence in the 3' untranslated region of the primate beta-globin nRNA is several times lower than the rate calculated for this region from other comparisons. The low rate of sequence divergence in the noncoding 3' end of the primate beta-globin mRNAs may indicate a specialized and significant function for this region in the higher primates.
我们已经对来自卷尾猴、恒河猴和黑猩猩的β-珠蛋白mRNA的3'和5'非翻译区进行了测序。与相应的人类序列进行比较发现，高等灵长类动物之间的序列分歧率在3'和5'非编码区是相同的，并且这个速率比编码区沉默替换的速率低几倍。此外，灵长类β-珠蛋白nRNA的3'非翻译区的序列分歧率比从其他比较中计算出的该区域的速率低几倍。灵长类β-珠蛋白mRNA非编码3'端的低序列分歧率可能表明该区域在高等灵长类动物中具有特殊且重要的功能。
