[实验性动脉粥样硬化家兔血液中的胆固醇生物合成]
[Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis].
作者信息
Mironova V N, Chaialo P P
出版信息
Biull Eksp Biol Med. 1978 Dec;86(12):689-91.
PMID:728610
Abstract
Blood of normal rabbits and those on atherogenic cholesterol diet was incubated with 2--14C-acetate of sodium. After incubation cholesterol and its precursors -- squalene and lanosterin -- were found and identified in the non-saponified fractions of leukocytes and platelets. The maximum specific activity was revealed in cholesterol, next in turn were lanosterin and squalene of leukocytes both in the normal rabbits and in those with atherosclerosis. In platelets the label was mainly accumulated in lanosterin.
摘要
将正常兔子和食用致动脉粥样硬化胆固醇饮食的兔子的血液与2--14C-醋酸钠一起孵育。孵育后，在白细胞和血小板的非皂化部分中发现并鉴定出胆固醇及其前体——角鲨烯和羊毛甾醇。正常兔子和患有动脉粥样硬化的兔子中，胆固醇的比活性最高，其次是白细胞中的羊毛甾醇和角鲨烯。在血小板中，标记物主要积聚在羊毛甾醇中。
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