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培养物中同时存在结核菌素纯蛋白衍生物（PPD）时对PHA诱导的淋巴细胞增殖的抑制作用。

Suppression of PHA-induced lymphocyte blastogenesis by concomitant presence of PPD in the culture.

作者信息

Aoki N, DeGroot L J

出版信息

Experientia. 1981;37(8):901-3. doi: 10.1007/BF01985704.

DOI:10.1007/BF01985704
PMID:7286152
Abstract

PHA-induced lymphocyte blastogenic response was remarkably suppressed by the simultaneous presence of PPD in cultures of lymphocytes derived from individuals sensitized to PPD, but not affected by the presence of PPD when the cultures contained lymphocytes from an individual not sensitized to the protein. This double stimulation blastogenesis study with PHA and a specific antigen is feasible as a simple and rapid test to measure cell-mediated immunity to the antigen.

摘要

在对结核菌素纯蛋白衍生物（PPD）致敏个体的淋巴细胞培养物中，PPD的同时存在显著抑制了PHA诱导的淋巴细胞增殖反应，但当培养物中含有未对该蛋白致敏个体的淋巴细胞时，PPD的存在对其没有影响。这项使用PHA和特定抗原的双重刺激增殖试验作为一种简单快速的检测方法来测量对抗原的细胞介导免疫是可行的。

相似文献

1
Suppression of PHA-induced lymphocyte blastogenesis by concomitant presence of PPD in the culture.培养物中同时存在结核菌素纯蛋白衍生物（PPD）时对PHA诱导的淋巴细胞增殖的抑制作用。
Experientia. 1981;37(8):901-3. doi: 10.1007/BF01985704.
2
Multiple lymphocyte transformation tests by phytohemagglutinin in healthy individuals: transient episodes of decreased lymphocyte blastogenesis.
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Acta Haematol. 1981;66(2):73-80. doi: 10.1159/000207101.
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Biol Reprod. 1984 Jun;30(5):1175-86. doi: 10.1095/biolreprod30.5.1175.
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J Immunogenet. 1979 Jun;6(3):197-214. doi: 10.1111/j.1744-313x.1979.tb00345.x.
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Effect of serum source on protein-free diet lymphocyte blastogenesis.血清来源对无蛋白饮食淋巴细胞增殖的影响。
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Spontaneous production of a suppressor factor by a human macrophage-like cell line U937. II. Suppression of antigen- and mitogen-induced blastogenesis, IL 2 production and IL 2 receptor expression in T lymphocytes.人巨噬细胞样细胞系U937自发产生抑制因子。II. 对T淋巴细胞中抗原和丝裂原诱导的母细胞化、白细胞介素2产生及白细胞介素2受体表达的抑制作用
J Immunol. 1987 Jan 1;138(1):197-203.

本文引用的文献

1
Antigen-induced suppression of the in vitro lymphocyte response to different antigens and mitogens.抗原诱导的对不同抗原和有丝分裂原的体外淋巴细胞反应的抑制作用。
Immunology. 1972 Mar;22(3):441-56.
2
Studies on suppressor cell function in thyroid diseases.
J Clin Endocrinol Metab. 1979 May;48(5):803-10. doi: 10.1210/jcem-48-5-803.
3
PPD-induced blastogenesis is auto-regulated by suppressor cells generated in vitro.PPD诱导的母细胞形成由体外产生的抑制细胞自动调节。
Experientia. 1979 Nov 15;35(11):1515-7. doi: 10.1007/BF01962819.
4
Suppressor cells induced by purified protein derivative of tuberculin (PPD): the suppression is mediated by cells that proliferate in response to stimulation with PPD.
Scand J Immunol. 1979;10(2):171-8. doi: 10.1111/j.1365-3083.1979.tb03272.x.
5
Suppressor T-cells in BCG-infected mice.卡介苗感染小鼠中的抑制性T细胞。
Infect Immun. 1979 Aug;25(2):491-6. doi: 10.1128/iai.25.2.491-496.1979.