Sonin B V
Farmakol Toksikol. 1981 May-Jun;44(3):347-53.
Experiments on 220 chick embryos were made to study the embryotoxic action of ethyl alcohol and nicotine administered alone and combined, depending on the drug dose, route and frequency of administration. It has been disclosed that the toxic effect of the drugs manifests primarily at the cellular and subcellular levels and mainly affects the cardiovascular system and liver. The drug side effects increased on repeated administration. Combined use of alcohol and nicotine does not lead to potentiation of their toxic effect on the developing embryo.
对220只鸡胚进行了实验，以研究单独及联合使用乙醇和尼古丁时的胚胎毒性作用，具体取决于药物剂量、给药途径和给药频率。已发现这些药物的毒性作用主要在细胞和亚细胞水平表现出来，并且主要影响心血管系统和肝脏。重复给药时药物副作用增加。乙醇和尼古丁联合使用不会导致其对发育中胚胎的毒性作用增强。
