Kukes V G, Gneushev E T, Utlinskaia M G, Burian E F, Starodubtsev A K
Farmakol Toksikol. 1981 Jul-Aug;44(4):447-50.
It has been shown with special reference to 35 patients suffering from myocardial infarction, atherosclerotic cardiosclerosis and rheumatic heart diseases associated with varying degrees of circulatory insufficiency that the final amount of distribution and halflife of lidocaine directly correlated with the cardiac index. A formula has been suggested for calculating the amount of distribution of the drug on the basis of the cardiac index. It has been demonstrated that the formula can be used for the development of therapeutically effective lidocaine concentration in the patients' blood.
针对35例患有心肌梗死、动脉粥样硬化性心肌病和风湿性心脏病并伴有不同程度循环功能不全的患者进行研究，结果表明利多卡因的最终分布量和半衰期与心脏指数直接相关。已提出一个根据心脏指数计算该药物分布量的公式。已证明该公式可用于确定患者血液中具有治疗效果的利多卡因浓度。
