Devoĭno L V, Al'perina E L
Farmakol Toksikol. 1980 Sep-Oct;43(5):590-2.
It has been established that injection of apomorphine leads to the dose-dependent enhancement of the immune response in CBA mice whereas that of haloperidol suppresses the number of rosette-forming cells. After thymectomy apomorphine does not stimulate rosette-formation. This indicates that the thymus participates in the realization of apomorphine action. Preliminary injection of haloperidol prevents the apomorphine-induced enhancement of the immune response. The results suggest that the enhancement is mediated through the activation of dopamine receptors.
已经确定，注射阿扑吗啡会导致CBA小鼠的免疫反应呈剂量依赖性增强，而注射氟哌啶醇则会抑制玫瑰花结形成细胞的数量。胸腺切除术后，阿扑吗啡不会刺激玫瑰花结形成。这表明胸腺参与了阿扑吗啡作用的实现。预先注射氟哌啶醇可防止阿扑吗啡诱导的免疫反应增强。结果表明，这种增强是通过多巴胺受体的激活介导的。
