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[阿扑吗啡与氟哌啶醇对免疫反应的影响]

[Effect of apomorphine and haloperidol on the immune reaction].

作者信息

Devoĭno L V, Al'perina E L

出版信息

Farmakol Toksikol. 1980 Sep-Oct;43(5):590-2.

PMID:7449989
Abstract

It has been established that injection of apomorphine leads to the dose-dependent enhancement of the immune response in CBA mice whereas that of haloperidol suppresses the number of rosette-forming cells. After thymectomy apomorphine does not stimulate rosette-formation. This indicates that the thymus participates in the realization of apomorphine action. Preliminary injection of haloperidol prevents the apomorphine-induced enhancement of the immune response. The results suggest that the enhancement is mediated through the activation of dopamine receptors.

摘要

已经确定,注射阿扑吗啡会导致CBA小鼠的免疫反应呈剂量依赖性增强,而注射氟哌啶醇则会抑制玫瑰花结形成细胞的数量。胸腺切除术后,阿扑吗啡不会刺激玫瑰花结形成。这表明胸腺参与了阿扑吗啡作用的实现。预先注射氟哌啶醇可防止阿扑吗啡诱导的免疫反应增强。结果表明,这种增强是通过多巴胺受体的激活介导的。

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