[Early triggering of the immune mechanism of chemical homeostasis in response to exo- and endogenous chemical compounds].

An early triggering of the immune mechanism of chemical homeostasis occurs in response to intravenous, intraperitoneal or intramuscular injection of drugs affecting the content of endogenous compounds of the mediator, enzymatic and hormonal type. This response is accompanied by morphological and functional changes in lymphoid cells of blood and organs as confirmed by immune rosette-formation and blast transformation, by variation of intercellular interactions that manifest in activation of immunocytoadhesion, in an increase in the titers of antibodies to the drug administered and in those of autoantibodies to the endogenous compounds that realize the drug effect. It has been shown that lymphocyte receptors specific for the endo- and exogenous compounds participate in the cell immune response to a chemical agent that might be pharmacologically monitored by means of the action of antagonists of the endogenous mediators on the receptor structure.