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[药物物质作用机制中的免疫和自身免疫反应、它们的解毒作用以及对其产生成瘾的发展过程]

[Immune and autoimmune reactions in the mechanism of action of drug substances, their detoxication and the development of habituation to them].

作者信息

Zaks A S, Bykova A A, Evteeva T A

出版信息

Farmakol Toksikol. 1979 Sep-Oct;42(5):541-5.

PMID:488333
Abstract

It has been shown that rausedyl administration is followed by enhanced synthesis of autoantibodies to serotonine and adrenaline. Meanwhile bucarban enhances the synthesis of autoantibodies to endogenous insulin and ACTH to hydrocortisone and testosterone. Activation of the autoimmune system of regulating the balance of endogenous compounds was shown by an increased number of specific antibody-producing cells in the organs and tissues and by the growth of the titer of circulating antibodies in the blood.

摘要

已表明,使用劳塞地尔后,血清素和肾上腺素自身抗体的合成会增强。同时,布卡班可增强内源性胰岛素、促肾上腺皮质激素、氢化可的松和睾酮自身抗体的合成。器官和组织中产生特异性抗体的细胞数量增加以及血液中循环抗体滴度升高,表明调节内源性化合物平衡的自身免疫系统被激活。

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