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Liver production of N-alkylated porphyrins caused in mice by treatment with substituted dihydropyridines. Evidence that the alkyl group on the pyrrole nitrogen atom originates from the drug.

作者信息

De Matteis F, Gibbs A H, Farmer P B, Lamb J H

出版信息

FEBS Lett. 1981 Jul 6;129(2):328-31. doi: 10.1016/0014-5793(81)80194-9.

DOI:10.1016/0014-5793(81)80194-9
PMID:7286222
Abstract
摘要

相似文献

1
Liver production of N-alkylated porphyrins caused in mice by treatment with substituted dihydropyridines. Evidence that the alkyl group on the pyrrole nitrogen atom originates from the drug.用取代二氢吡啶处理小鼠后肝脏中N-烷基化卟啉的产生。吡咯氮原子上的烷基源自药物的证据。
FEBS Lett. 1981 Jul 6;129(2):328-31. doi: 10.1016/0014-5793(81)80194-9.
2
Inactivation of cytochrome P-450 and production of N-alkylated porphyrins caused in isolated hepatocytes by substituted dihydropyridines. Structural requirements for loss of haem and alkylation of the pyrrole nitrogen atom.取代二氢吡啶在分离的肝细胞中引起的细胞色素P-450失活及N-烷基化卟啉的生成。血红素丢失和吡咯氮原子烷基化的结构要求。
FEBS Lett. 1982 Aug 16;145(1):87-92. doi: 10.1016/0014-5793(82)81212-x.
3
Studies on the inhibition of ferrochelatase by N-alkylated dicarboxylic porphyrins. Steric factors involved and evidence that the inhibition is reversible.N-烷基化二羧酸卟啉对亚铁螯合酶的抑制作用研究。相关空间因素及抑制作用可逆的证据。
Biochem J. 1985 Mar 1;226(2):537-44. doi: 10.1042/bj2260537.
4
Isomeric composition of N-alkylated protoporphyrins produced by substituted dihydropyridines in vivo and in vitro.体内和体外由取代二氢吡啶产生的N-烷基化原卟啉的异构体组成。
Adv Exp Med Biol. 1986;197:163-70. doi: 10.1007/978-1-4684-5134-4_13.
5
Ferrochelatase and N-alkylated porphyrins.亚铁螯合酶与N-烷基化卟啉
Mol Cell Biochem. 1984 Sep;64(2):127-37. doi: 10.1007/BF00224769.
6
Conversion of liver haem into N-substituted porphyrins or green pigments. Nature of the substituent at the pyrrole nitrogen atom.肝脏血红素转化为N-取代卟啉或绿色色素。吡咯氮原子上取代基的性质。
FEBS Lett. 1980 Sep 22;119(1):109-12. doi: 10.1016/0014-5793(80)81009-x.
7
Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes.卟啉诱导药物对分离的小鼠肝细胞中铁螯合酶活性的影响。
Can J Physiol Pharmacol. 1981 Nov;59(11):1155-8. doi: 10.1139/y81-178.
8
Inhibition of protohaem ferro-lyase by N-substituted porphyrins. Structural requirements for the inhibitory effect.N-取代卟啉对原血红素铁裂解酶的抑制作用。抑制效应的结构要求。
Biochem J. 1980 Sep 1;189(3):645-8. doi: 10.1042/bj1890645.
9
N-alkylation of the haem moiety of cytochrome P-450 caused by substituted dihydropyridines. Preferential attack of different pyrrole nitrogen atoms after induction of various cytochrome P-450 isoenzymes.取代二氢吡啶引起的细胞色素P-450血红素部分的N-烷基化。诱导各种细胞色素P-450同工酶后不同吡咯氮原子的优先攻击。
Biochem J. 1983 May 1;211(2):455-61. doi: 10.1042/bj2110455.
10
N-alkylation of exogenous haem analogues caused by drugs in isolated hepatocytes. Structural isomerism and chirality of the resulting porphyrins.药物在分离的肝细胞中引起的外源性血红素类似物的N-烷基化。所得卟啉的结构异构和手性。
Biochem J. 1986 Aug 15;238(1):263-8. doi: 10.1042/bj2380263.

引用本文的文献

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Complex response to physiological and drug-induced hepatic heme demand in monoallelic mice.单等位基因小鼠对生理和药物诱导的肝脏血红素需求的复杂反应。
Mol Genet Metab Rep. 2021 Nov 12;29:100818. doi: 10.1016/j.ymgmr.2021.100818. eCollection 2021 Dec.
2
The association between chemical-induced porphyria and hepatic cancer.化学诱导的卟啉症与肝癌之间的关联。
Toxicol Res (Camb). 2018 Jun 1;7(4):647-663. doi: 10.1039/c8tx00019k. eCollection 2018 Jul 1.
3
Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.
Arch Toxicol. 1993;67(3):179-85. doi: 10.1007/BF01973305.
4
Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice.从服用灰黄霉素的小鼠肝脏中分离出的N-取代原卟啉结构的测定。
Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):505-12. doi: 10.1042/bj3070505.
5
Formation of N-alkylated protoporphyrin IX in the livers of mice after diethylnitrosamine treatment.二乙基亚硝胺处理后小鼠肝脏中N-烷基化原卟啉IX的形成。
Biochem J. 1983 Jun 15;212(3):599-608. doi: 10.1042/bj2120599.
6
N-alkylation of the haem moiety of cytochrome P-450 caused by substituted dihydropyridines. Preferential attack of different pyrrole nitrogen atoms after induction of various cytochrome P-450 isoenzymes.取代二氢吡啶引起的细胞色素P-450血红素部分的N-烷基化。诱导各种细胞色素P-450同工酶后不同吡咯氮原子的优先攻击。
Biochem J. 1983 May 1;211(2):455-61. doi: 10.1042/bj2110455.
7
Drug-induced accumulation of uroporphyrin in chicken hepatocyte cultures. Structural requirements for the effect and role of exogenous iron.药物诱导鸡肝细胞培养物中尿卟啉的积累。外源性铁的作用及效应的结构要求。
Biochem J. 1984 Dec 15;224(3):769-77. doi: 10.1042/bj2240769.
8
Quantitative analysis of flux along the gluconeogenic, glycolytic and pentose phosphate pathways under reducing conditions in hepatocytes isolated from fed rats.对从喂食大鼠分离出的肝细胞在还原条件下沿糖异生、糖酵解和磷酸戊糖途径的通量进行定量分析。
Biochem J. 1983 Jun 15;212(3):585-98. doi: 10.1042/bj2120585.
9
Ferrochelatase and N-alkylated porphyrins.亚铁螯合酶与N-烷基化卟啉
Mol Cell Biochem. 1984 Sep;64(2):127-37. doi: 10.1007/BF00224769.
10
Olfactory cytochrome P-450. Studies with suicide substrates of the haemoprotein.嗅觉细胞色素P-450。血红素蛋白自杀底物的研究。
Biochem J. 1988 Jul 15;253(2):569-76. doi: 10.1042/bj2530569.