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三种不同年龄组雄性丽斑麻蜥肝脏呼吸代谢的热失活和草酰乙酸抑制作用

Thermal inactivation and oxaloacetate inhibition of hepatic respiratory metabolism in male garden lizards of three different age-groups.

作者信息

Kara T C, Patnaik B K

出版信息

Gerontology. 1981;27(4):187-93. doi: 10.1159/000212472.

DOI:10.1159/000212472
PMID:7286649
Abstract

Thermal inactivation of hepatic succinic dehydrogenase (SH) (EC 1.3.99.1) at 51 +/- 1 degrees C resulted in a higher degree of inhibition in middle-aged and old than in young lizards. The oxaloacetate inhibition of SDH activity and that of oxygen uptake of liver homogenates after 1 h of incubation also showed a similar pattern of age dependency. With increase in time interval (from 15 to 60 min) the young and to some extent the middle-aged lizards showed a partial recovery from inhibition of oxygen consumption of liver homogenates, but not the old animals.

摘要

在51±1℃下对肝琥珀酸脱氢酶（SH）（EC 1.3.99.1）进行热失活处理，结果发现中年和老年蜥蜴受到的抑制程度高于幼年蜥蜴。孵育1小时后，草酰乙酸对肝匀浆中琥珀酸脱氢酶活性及氧摄取的抑制作用也呈现出类似的年龄依赖性模式。随着时间间隔增加（从15分钟到60分钟），幼年蜥蜴以及在一定程度上中年蜥蜴的肝匀浆氧消耗抑制有部分恢复，但老年蜥蜴没有。

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