Trewby P N, Chipping P M, Palmer S J, Roberts P D, Lewis S M, Stewart J S
Gut. 1981 Aug;22(8):628-32. doi: 10.1136/gut.22.8.628.
A study of splenic function in 28 patients with adult coeliac disease showed no significant correlation between the half life of heat-damaged red cells and either the duration of pre-treatment exposure to gluten or the length of time on a gluten free diet. A significant correlation was found between splenic size and duration of treatment; those patients who had been taking a gluten free diet for the longest time had the smallest spleens. Blood films from 11 of these 28 patients taken before treatment with a gluten free diet were compared with those taken between two and 15 years after the start of treatment. There was no tendency for the hyposplenic changes to regress. In the majority, the changes became more prominent despite strict adherence to the gluten free diet. These findings suggest that splenic atrophy in adult coeliac disease is not reversed by treatment with a gluten free diet and is unlikely to be related to the state of the jejunal mucosa or the duration of initial exposure to gluten.
一项针对28例成人乳糜泻患者脾脏功能的研究表明，热损伤红细胞的半衰期与治疗前接触麸质的持续时间或无麸质饮食的时长均无显著相关性。研究发现脾脏大小与治疗持续时间之间存在显著相关性；那些无麸质饮食时间最长的患者脾脏最小。将这28例患者中11例在无麸质饮食治疗前采集的血涂片与开始治疗后2至15年采集的血涂片进行比较。脾功能低下的改变没有恢复的趋势。在大多数情况下，尽管严格遵循无麸质饮食，这些改变仍变得更加明显。这些发现表明，成人乳糜泻中的脾萎缩不会通过无麸质饮食治疗而逆转，并且不太可能与空肠黏膜状态或最初接触麸质的持续时间有关。
