泮库溴铵对去脑大鼠心血管系统的拟交感神经效应：与去甲肾上腺素神经元摄取阻断药物效应的比较
Sympathomimetic effects of pancuronium bromide on the cardiovascular system of the pithed rat: a comparison with the effects of drugs blocking the neuronal uptake of noradrenaline.
作者信息
Docherty J R, McGrath J C
出版信息
Br J Pharmacol. 1978 Dec;64(4):589-99. doi: 10.1111/j.1476-5381.1978.tb17321.x.
Abstract
- The effects of pancuronium bromide on the cardiovascular system of the pithed rat were examined. Pancuronium had two effects, a short-lasting cardiovascular stimulation following injection and a longer-lasting potentiation of responses to sympathetic nerve stimulation. 2 The initial effect of pancuronium was compared with that of tyramine. The cardioaccelerator but not the pressor responses to both pancuronium and tyramine were significantly reduced following sympathectomy with 6-hydroxydopamine (6-OHDA). 3 The action of pancuronium in potentiating sympathetic nerve responses was compared with that of known blockers of the neuronal uptake of noradrenaline (NA). Pancuronium (1 mg/kg) and cocaine (0.5 mg/kg) potentiated cardioaccelerator and pressor responses to sympathetic stimulation. These effects of pancuronium could be obtained following adrenalectomy and during neuromuscular blockade with gallamine. Pancuronium and uptake blockers potentiated the cardioaccelerator response to NA, reduced the response to tyramine, but did not affect the response to isoprenaline. Pancuronium and uptake blockers potentiated the pressor response to NA, but did not affect the response to tyramine or clonidine. 4 Following sympathectomy with 6-OHDA, pancuronium failed to potentiate cardioaccelerator and pressor responses to NA. 5 These results are discussed in relation to two main cardiovascular effects of pancuronium; an indirect sympathomimetic action and blockade of the neuronal uptake of NA.
摘要
- 研究了泮库溴铵对脊髓横断大鼠心血管系统的影响。泮库溴铵有两种作用，注射后有短暂的心血管刺激作用，以及对交感神经刺激反应的持久增强作用。2. 将泮库溴铵的初始作用与酪胺的作用进行了比较。用6-羟基多巴胺（6-OHDA）进行交感神经切除后，泮库溴铵和酪胺的心脏加速反应而非升压反应均显著降低。3. 将泮库溴铵增强交感神经反应的作用与已知的去甲肾上腺素（NA）神经元摄取阻滞剂的作用进行了比较。泮库溴铵（1mg/kg）和可卡因（0.5mg/kg）增强了对交感神经刺激的心脏加速反应和升压反应。泮库溴铵的这些作用在肾上腺切除后以及用加拉明进行神经肌肉阻滞期间均可出现。泮库溴铵和摄取阻滞剂增强了对NA的心脏加速反应，降低了对酪胺的反应，但不影响对异丙肾上腺素的反应。泮库溴铵和摄取阻滞剂增强了对NA的升压反应，但不影响对酪胺或可乐定的反应。4. 用6-OHDA进行交感神经切除后，泮库溴铵未能增强对NA的心脏加速反应和升压反应。5. 结合泮库溴铵的两种主要心血管作用对这些结果进行了讨论；一种间接拟交感神经作用和对NA神经元摄取的阻断作用。
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Potentiation of tyramine effect on the isolated iris muscle by cocaine.可卡因对可卡因增强酪胺对离体虹膜肌的作用。 （注：此译文感觉原英文表述不太准确完整，如果是 “Potentiation of the tyramine effect on the isolated iris muscle by cocaine.” 可能更合理，译文为“可卡因对酪胺作用于离体虹膜肌的增强效应” ） 按照你要求严格翻译为当前译文 ： 可卡因对酪胺对离体虹膜肌的作用增强。 但这样表述较怪异 ，建议确认下英文原文是否准确 。
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A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat.一种在脊髓被破坏的猫和大鼠中刺激从脊柱到各个器官的自主神经传出不同节段的方法。
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The spinal origin of the motor and inhibitory innervation of the rat anococcygeus muscles.大鼠肛门尾骨肌运动及抑制性神经支配的脊髓起源
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A technique for the study of muscle relaxants by stimulating the spinal motor nerve outflow in the pithed rat.一种通过刺激脊髓麻醉大鼠的脊髓运动神经传出纤维来研究肌肉松弛剂的技术。
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Comparison of haemodynamic effects of alpha-sympathomimetic drugs.α-拟交感神经药物血流动力学效应的比较
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