Sharma H S, Dey P K
Indian J Physiol Pharmacol. 1981 Apr-Jun;25(2):111-22.
Influence of immobilization stress on blood-brain barrier (BBB) was studied in rats using Evans blue as barrier tracer. 7-9 hr of of immobilization had increased the permeability of BBB mainly in younger rats. This increased permeability was significantly reduced with p-CPA, indomethacin or vinblastine pretreatment. Theophylline treatment caused early extravasation of Evans blue dye. The increased level of serotonin in immobilization and infusion of 5-HT in model experiments suggest a causative role of serotonin in the increased permeability of BBB induced by immobilization stress.
采用伊文思蓝作为屏障示踪剂，研究了制动应激对大鼠血脑屏障（BBB）的影响。7 - 9小时的制动主要增加了幼龄大鼠血脑屏障的通透性。用对氯苯丙氨酸、吲哚美辛或长春碱预处理可显著降低这种增加的通透性。茶碱处理导致伊文思蓝染料早期外渗。制动时血清素水平升高以及在模型实验中输注5 - 羟色胺表明血清素在制动应激诱导的血脑屏障通透性增加中起因果作用。
