Ambrosioni E, Tartagni F, Lusa A M, Bassein L, Magnani B
Int J Clin Pharmacol Ther Toxicol. 1981 Oct;19(10):445-9.
The K-sparing effects of amiloride (A) and triamterene (T) associated with tienilic acid (C) are studied, along with their effects on diuresis and on the urinary excretion of uric acid, Mg, Na, Cl, P, and Ca. Eighteen hospitalized patients, divided into two groups of nine, received the following dosages of the drugs. The first group took 250 mg of C (equivalent to 50 mg hydrochlorothiazide), 5 mg of A and 100 mg of T; the second received double doses of both A and T but the same dose of C. Each treatment was administered on 2 not necessarily consecutive days, so as to have a total of 6 days of treatment per patient according to a balanced randomized design identical for the two groups. The data were obtained from urine collected during the first 8 h after the drug was administered, and during the following 16 h. A and T showed a significant K-sparing effect (p less than 0.01) only for the second group, and only at the higher dosages were minor effects on the urinary excretion of uric acid, Mg, and Cl noted (p less than 0.05). The association of A or T with C was well tolerated, and no important side effects were observed.
研究了阿米洛利（A）和氨苯蝶啶（T）与替尼酸（C）联用的保钾作用，以及它们对利尿和尿酸、镁、钠、氯、磷和钙尿排泄的影响。18名住院患者分为两组，每组9人，接受以下剂量的药物。第一组服用250毫克C（相当于50毫克氢氯噻嗪）、5毫克A和100毫克T；第二组服用的A和T剂量加倍，但C剂量相同。每种治疗在2个不一定连续的日子进行，以便根据两组相同的平衡随机设计，每位患者总共接受6天的治疗。数据来自给药后最初8小时以及随后16小时收集的尿液。仅第二组中，A和T在较高剂量时才显示出显著的保钾作用（p小于0.01），并且对尿酸、镁和氯的尿排泄仅有轻微影响（p小于0.05）。A或T与C联用耐受性良好，未观察到重要的副作用。
