Palestine A G, Brubaker R F
Invest Ophthalmol Vis Sci. 1981 Oct;21(4):542-9.
The pharmacokinetics of fluorescein in the vitreous after intravenous or oral fluorescein administration was studied in normal individuals. Vitreous and free blood fluorescein concentrations were measured over an 8 hr period by fluorophotometry and fluorescence polarization. A computer model was constructed based on the free plasma fluorescein concentrations and conformed closely to the experimental data. The concentration profiles of fluorescein appearance in the vitreous were then examined. The effect of alterations in retinal permeability and free blood fluorescein concentration are also discussed. This article illustrates that an increase in the concentration of fluorescein in the vitreous as measured by fluorophotometry can be caused by factors other than an increase in blood-retinal barrier permeability.
在正常个体中研究了静脉注射或口服荧光素后荧光素在玻璃体中的药代动力学。通过荧光光度法和荧光偏振在8小时内测量玻璃体和游离血中荧光素的浓度。基于游离血浆荧光素浓度构建了一个计算机模型，该模型与实验数据紧密相符。然后检查了荧光素在玻璃体中出现的浓度曲线。还讨论了视网膜通透性改变和游离血中荧光素浓度的影响。本文表明，通过荧光光度法测量的玻璃体中荧光素浓度的增加可能由血视网膜屏障通透性增加以外的因素引起。
