van Gelder N M, Drujan B D
Brain Res. 1978 Dec 22;159(1):137-48. doi: 10.1016/0006-8993(78)90115-4.
Examination of interrelated changes in the concentrations of 'clusters' of amino acids provides evidence that individual amino acid levels in the tissues cannot be considered to vary independently. Such variations are observed when the CNS at 'rest' is stimulated. Alterations in taurine cause changes in glutamic acid and also modify its anatomically related compartmentalized metabolism. Similar interdependent modifications may be indicated for the concentrations of 3 biochemically related neutral amino acids: threonine, serine and glycine. With specific reference to the fish optic tectum and retina, certain differences and coincidences in the regulation of GABA and glycine have also been uncovered. Finally, many of the findings presented here are closely analogous to results obtained when comparing normal and epileptic mammalian tissues. Possibly, this analogy can be attributed to the fact that the physiological states so far investigated, from the most simplistic point of view, represent extreme variations of nervous tissue excitation.
对氨基酸“簇”浓度的相关变化进行检测，结果表明组织中单个氨基酸水平并非独立变化。当“静息”的中枢神经系统受到刺激时，就会观察到这种变化。牛磺酸的改变会引起谷氨酸的变化，也会改变其在解剖学上相关的分区代谢。对于三种生物化学相关的中性氨基酸（苏氨酸、丝氨酸和甘氨酸）的浓度，可能也存在类似的相互依存性修饰。特别提及鱼类视顶盖和视网膜，在γ-氨基丁酸（GABA）和甘氨酸的调节方面也发现了某些差异和一致性。最后，本文呈现的许多研究结果与比较正常和癫痫性哺乳动物组织时获得的结果极为相似。从最简化的角度来看，这种相似性可能归因于这样一个事实，即迄今为止所研究的生理状态代表了神经组织兴奋的极端变化。
