Hasan M, Sircus W
J Clin Gastroenterol. 1981 Sep;3(3):225-9. doi: 10.1097/00004836-198109000-00005.
Why a substantial proportion of peptic ulcers fails to heal in clinical trials of drugs remains uncertain. We therefore made a prospective study of biological and social factors which might influence healing. 160 patients who were treated with cimetidine for various types of peptic ulceration were grouped into successes or failures by serial endoscopic review. There were 80 patients in each group. Significant differences between the two groups emerged. The mean age and mean age of onset of symptoms were lower in the failure group. The proportion of manual workers and artisans, the frequency of family history of peptic ulcer, the proportion of smokers, alcohol users, analgesic takers, and the frequency of acid hypersecretion were all higher in the failure group. The "degree" of abuse of smoking, alcohol, and analgesics was also greater in the failures than in the successes. The proportional reduction of maximal acid output after a dose of cimetidine was not different between the groups.
在药物临床试验中，为何相当一部分消化性溃疡未能愈合仍不明确。因此，我们对可能影响愈合的生物学和社会因素进行了一项前瞻性研究。160例因各种类型消化性溃疡接受西咪替丁治疗的患者，通过连续内镜检查分为愈合组和未愈合组。每组80例。两组之间出现了显著差异。未愈合组的平均年龄和症状出现的平均年龄较低。未愈合组体力劳动者和工匠的比例、消化性溃疡家族史的频率、吸烟者、饮酒者、服用镇痛药者的比例以及胃酸分泌过多的频率均较高。未愈合组吸烟、饮酒和服用镇痛药的“滥用程度”也高于愈合组。两组在服用一剂西咪替丁后最大酸排量的比例降低并无差异。
