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甾醇合成。一种合成24,25-二氢羊毛甾醇32-氧化衍生物的简化方法。

Sterol synthesis. A simplified method for the synthesis of 32-oxygenated derivatives of 24,25-dihydrolanosterol.

作者信息

Parish E J, Schroepfer G J

出版信息

J Lipid Res. 1981 Jul;22(5):859-68.

PMID:7288292
Abstract

A simplified method is described for the preparation of 14 alpha-hydroxymethyl-4,4-dimethyl-5 alpha-cholest-8-en-e beta-ol, 14 alpha-hydroxymethyl-4,4-dimethyl-5 alpha-cholest-7-en-3 beta-ol, and 14 alpha-hydroxymethyl-4,4-dimethyl-5-alpha-cholest-6-en-3 beta-ol from commercial lanosterol. This method represents a modification of the approach introduced by Fried and co-workers (Fried, J., J. W. Brown, and L. Borkenhagen. 1965. Tetrahedron Lett. 2499-2504).

摘要

描述了一种从市售羊毛甾醇制备14α-羟甲基-4,4-二甲基-5α-胆甾-8-烯-3β-醇、14α-羟甲基-4,4-二甲基-5α-胆甾-7-烯-3β-醇和14α-羟甲基-4,4-二甲基-5α-胆甾-6-烯-3β-醇的简化方法。该方法是对Fried及其同事(Fried, J., J. W. Brown, and L. Borkenhagen. 1965. Tetrahedron Lett. 2499 - 2504)所引入方法的改进。

相似文献

1
Sterol synthesis. A simplified method for the synthesis of 32-oxygenated derivatives of 24,25-dihydrolanosterol.甾醇合成。一种合成24,25-二氢羊毛甾醇32-氧化衍生物的简化方法。
J Lipid Res. 1981 Jul;22(5):859-68.
2
Inhibitors of sterol synthesis. Differential effects of 14 alpha-hydroxymethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol and 14 alpha-hydroxymethyl-5 alpha-cholest-6-ene-3 beta, 15 alpha-diol on sterol synthesis in cell-free homogenates of rat liver.固醇合成抑制剂。14α-羟甲基-5α-胆甾-7-烯-3β,15α-二醇和14α-羟甲基-5α-胆甾-6-烯-3β,15α-二醇对大鼠肝脏无细胞匀浆中固醇合成的不同影响。
J Biol Chem. 1981 Aug 10;256(15):8085-91.
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Inhibition of sterol biosynthesis in animal cells by 14 alpha-hydroxymethyl sterols.14α-羟甲基甾醇对动物细胞中甾醇生物合成的抑制作用。
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Peroxisomal cholesterol synthesis in vivo: accumulation of 4-methyl intermediate sterols after aminotriazole inhibition of cholesterol synthesis.体内过氧化物酶体胆固醇合成:氨基三唑抑制胆固醇合成后4-甲基中间甾醇的积累
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A simplified synthesis of 32-oxygenated lanosterol derivatives.32-氧化羊毛甾醇衍生物的简化合成
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Inhibitors of sterol synthesis. Spectral characterization of derivatives of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.
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Synthesis of lanosterol derivatives with a functional group at C-32, including an antineoplastic sterol, 3 beta-hydroxylanost-7-en-32-oic acid.具有C-32官能团的羊毛甾醇衍生物的合成,包括一种抗肿瘤甾醇,3β-羟基羊毛甾-7-烯-32-酸。
Chem Pharm Bull (Tokyo). 1991 Jan;39(1):100-3. doi: 10.1248/cpb.39.100.
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Effect of trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride and carbon monoxide on hepatic cholesterol biosynthesis from 4,4,-dimethyl sterols in vitro.反式-1,4-双(2-氯苄氨基甲基)环己烷二盐酸盐与一氧化碳对体外4,4'-二甲基甾醇肝胆固醇生物合成的影响
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Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation.酵母中纯化的细胞色素P-45014DM对32-羟基-24,25-二氢羊毛甾醇的代谢。细胞色素对羊毛甾醇14α-去甲基化全过程作用的证据。
J Biol Chem. 1987 Jan 25;262(3):1239-43.

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