Sonoda Y, Ichinose K, Yoshimura T, Sato Y, Sasaki T
Kyoritsu College of Pharmacy, Tokyo, Japan.
Chem Pharm Bull (Tokyo). 1991 Jan;39(1):100-3. doi: 10.1248/cpb.39.100.
Lanosterol derivatives with a functional group at C-32 have been synthesized from 3 beta-acetoxylanostan-7 alpha-ol. The key reaction of the synthesis is the hypoiodite reaction of 3 beta-acetoxylanostan-7 alpha-ol. In vitro antitumor activity testing of the lanosterol derivatives revealed that 3 beta-hydroxylanost-7-en-32-oic acid has antineoplastic activity.
已从3β-乙酰氧基羊毛甾烷-7α-醇合成了在C-32位带有官能团的羊毛甾醇衍生物。该合成的关键反应是3β-乙酰氧基羊毛甾烷-7α-醇的次碘酸盐反应。羊毛甾醇衍生物的体外抗肿瘤活性测试表明，3β-羟基羊毛甾-7-烯-32-酸具有抗肿瘤活性。
