Aminoff M J, Ochs A L
J Neurol Neurosurg Psychiatry. 1981 Jul;44(7):608-14. doi: 10.1136/jnnp.44.7.608.
Visual evoked potentials (VEPs) were obtained by monocular stimulation using a checkerboard pattern-reversal and pattern-onset technique. In 11 normal subjects, pattern-onset VEPs were generally larger, better defined, and less ambiguous than those elicited by pattern-reversal, because of the biphasic waveform characteristically obtained with pattern-onset stimulation. In 68 of 105 patients with possible multiple sclerosis, VEPs were normal in latency by both methods, and in nine adequate comparison was not possible. The incidence of normal VEPs to pattern-reversal was similar to that found in several other studies of patients with possible multiple sclerosis. Among the remaining 28 patients in whom VEP abnormalities were found, an increased latency was detected in 75% with the pattern-reversal technique, and in 96% by pattern-onset. In these patients, VEP abnormalities were obtained by monocular stimulation of each of 46 eyes, and among these the pattern-reversal technique yielded abnormalities in 59% and the pattern-onset method in 98%. These results indicate that VEPs elicited by pattern-onset are useful in investigating patients with suspected multiple sclerosis, and the diagnostic yield may be greater than with conventional pattern-reversal techniques.
视觉诱发电位（VEP）通过使用棋盘格模式反转和模式起始技术进行单眼刺激来获得。在11名正常受试者中，由于模式起始刺激通常获得双相波形，模式起始VEP通常比模式反转诱发的VEP更大、定义更清晰且更明确。在105例可能患有多发性硬化症的患者中，68例患者两种方法测得的VEP潜伏期均正常，9例无法进行充分比较。模式反转VEP正常的发生率与其他几项对可能患有多发性硬化症患者的研究结果相似。在其余28例发现VEP异常的患者中，模式反转技术检测到75%的患者潜伏期延长，模式起始技术检测到96%的患者潜伏期延长。在这些患者中，通过单眼刺激46只眼中的每只眼获得VEP异常，其中模式反转技术在59%的眼中检测到异常，模式起始方法在98%的眼中检测到异常。这些结果表明，模式起始诱发的VEP在调查疑似多发性硬化症患者时有用，并且诊断率可能高于传统的模式反转技术。
