缺铜大鼠血浆卵磷脂：胆固醇酰基转移酶活性降低。

Decreased plasma lecithin: cholesterol acyltransferase activity in copper-deficient rats.

作者信息

Harvey P W, Allen K G

出版信息

J Nutr. 1981 Oct;111(10):1855-8. doi: 10.1093/jn/111.10.1855.

DOI:10.1093/jn/111.10.1855

Abstract

The effect of dietary copper deficiency on rat plasma lecithin: cholesterol acyltransferase (LCAT) activity was examined. Three groups of rats were used: ad libitum-fed copper-deficient group (0.6 microgram Cu/g diet); pair-fed control group (5.9 microgram Cu/g diet); and an ad libitum-fed control group (5.9 microgram Cu/g diet). Copper deficiency produced a significant hypercholesterolemia (57% increase, P less than 0.001) in 63 days with a significant increase in plasma free cholesterol (44%, P less than 0.001). Despite the significant increase in plasma free cholesterol, fractional and molar LCAT activity were markedly decreased (74.2%, P less than 0.001 and 63.7%, P less than 0.005, respectively) in copper-deficient rats. The results of this study suggest that dietary copper deficiency affects LCAT activity.

摘要

研究了膳食铜缺乏对大鼠血浆卵磷脂胆固醇酰基转移酶（LCAT）活性的影响。使用了三组大鼠：自由采食铜缺乏组（饮食含铜量为0.6微克/克）；配对喂食对照组（饮食含铜量为5.9微克/克）；以及自由采食对照组（饮食含铜量为5.9微克/克）。63天后，铜缺乏导致显著的高胆固醇血症（增加57%，P<0.001），同时血浆游离胆固醇显著增加（44%，P<0.001）。尽管血浆游离胆固醇显著增加，但铜缺乏大鼠的LCAT活性分数和摩尔活性均显著降低（分别降低74.2%，P<0.00`1；降低63.7%，P<0.005）。本研究结果表明，膳食铜缺乏会影响LCAT活性。