Szczepańska-Sadowska E, Sobocińska J, Sadowski B, Kosowski S
Am J Physiol. 1979 Jan;236(1):R117-25. doi: 10.1152/ajpregu.1979.236.1.R117.
The effect of electrical brain stimulation (ESB; 50 Hz, 50-150 microA sine wave, 5 s on/5 s off) on osmotic thirst was examined in 10 conscious dogs chronically implanted with electrodes aimed at the anteromedial part of the basal forebrain. Suppression of osmotic thirst (SOT) was observed during stimulation through 18 of 41 electrodes located in the olfactory tubercle, the nucleus accumbens, the caudate nucleus, the medial septum, and the lateral preoptic-anterolateral hypothalamic area (PrA/ALH). Mean increment in plasma osmolality necessary to cause drinking rose from 9.0 +/- 1.5 mosmol (X +/- SE; n = 15) under control conditions to 15.8 +/- 2.6 mosmol (n = 18) during ESB in SOT placements. Threshold cellular dehydration eliciting drinking increased from 2.70 +/- 0.50% of intracellular water (ICW;n = 16) to 4.77 +/- 0.68% of ICW (n = 18), respectively. The strongest SOT was found during ESB in the nucleus accumbens, and the PrA/ALH. The same stimulation failed to inhibit feeding, support self-stimulation or produce appreciable changes of dog's gross behavior. The results give evidence for the existence in the basal forebrain of the dog a widely distributed neural system suppressing osmotic thirst. The nucleus accumbens and the PrA/ALH seem to play an important role in this system.
在10只长期植入电极并将其瞄准基底前脑内侧前部的清醒犬中，研究了脑电刺激（ESB；50Hz，50 - 150微安正弦波，5秒开/5秒关）对渗透性口渴的影响。在通过位于嗅结节、伏隔核、尾状核、内侧隔区以及外侧视前 - 下丘脑前外侧区（PrA/ALH）的41个电极中的18个进行刺激期间，观察到了渗透性口渴抑制（SOT）。在SOT植入部位进行ESB期间，引起饮水的血浆渗透压平均增加值从对照条件下的9.0±1.5毫摩尔/千克（X±SE；n = 15）升至15.8±2.6毫摩尔/千克（n = 18）。引发饮水的阈值细胞脱水分别从细胞内水（ICW）的2.70±0.50%（n = 16）增加到ICW的4.77±0.68%（n = 18）。在伏隔核和PrA/ALH进行ESB期间发现了最强的SOT。相同的刺激未能抑制进食、支持自我刺激或使犬的总体行为产生明显变化。结果证明在犬的基底前脑中存在一个广泛分布的抑制渗透性口渴的神经系统。伏隔核和PrA/ALH似乎在该系统中发挥重要作用。
