Cancer. 1978 Dec;42(6):2809-26. doi: 10.1002/1097-0142(197812)42:6<2809::aid-cncr2820420642>3.0.co;2-9.
A prospective study of factors that might be helpful in predicting recurrence of breast cancer during the 2 years after radical mastectomy has been completed in 381 women by the Cooperative Breast Cancer Group (National Cancer Institute). Identification of clinical factors which might be associated with such recurrence has been achieved. A multivariate analysis of the data was oriented toward the identification of clinical factors other than lymph node status that might be simultaneously used to predict recurrence because of the current trend of cancer therapy toward more limited surgery. Degree of differentiation of the tumor, blood vessel invasion, patient age and tumor size were identified as important predictors of recurrence for premenopausal patients and tumor size was identified as important for postmenopausal patients. The addition of axillary lymph node status to these factors, however, made a significant improvement in the prediction equation for both pre- and postmenopausal patients. Studies of this type are of particular value to understand further the biology of breast cancer which is necessary to develop rational primary and adjuvant treatment strategies.
美国国立癌症研究所合作乳腺癌小组对381名女性进行了一项前瞻性研究，以确定在根治性乳房切除术后2年内可能有助于预测乳腺癌复发的因素。现已确定了可能与此类复发相关的临床因素。由于目前癌症治疗趋向于更有限的手术，因此对数据进行多变量分析的目的是识别除淋巴结状态外的其他临床因素，这些因素可同时用于预测复发。肿瘤分化程度、血管侵犯、患者年龄和肿瘤大小被确定为绝经前患者复发的重要预测因素，而肿瘤大小被确定为绝经后患者复发的重要预测因素。然而，将腋窝淋巴结状态加入这些因素后，绝经前和绝经后患者的预测方程都有了显著改善。这类研究对于进一步了解乳腺癌生物学特性具有特殊价值，而这对于制定合理的原发性和辅助性治疗策略是必要的。
