Brown M P, Stover S M, Kelly R H, Farver T B
Am J Vet Res. 1981 Oct;42(10):1823-5.
Six healthy adult mares were given a single dose of kanamycin sulfate (200 mg/ml) IM at a dosage rate of 5 mg/kg of body weight. Kanamycin concentrations in serum, synovial fluid, peritoneal fluid, and urine were measured serially over a 48-hour period. The mean peak serum kanamycin concentration was 12.55 microgram/ml at 1 hour. Mean peak kanamycin concentrations in synovial fluid and peritoneal fluid were 7.25 microgram/ml and 9.27 microgram/ml at 2 hours and 3 hours, respectively. These concentrations decreased steadily in parallel with serum concentrations and were still measurable at 48 hours. Urine concentrations of kanamycin were relatively high, with a mean peak concentration of 80.51 microgram/ml at 1 hour.
给6匹健康成年母马以5毫克/千克体重的剂量肌肉注射单剂量硫酸卡那霉素（200毫克/毫升）。在48小时内连续测定血清、滑液、腹腔液和尿液中的卡那霉素浓度。1小时时血清卡那霉素平均峰值浓度为12.55微克/毫升。滑液和腹腔液中卡那霉素的平均峰值浓度分别在2小时和3小时时为7.25微克/毫升和9.27微克/毫升。这些浓度与血清浓度平行稳步下降，在48小时时仍可测量。卡那霉素的尿液浓度相对较高，1小时时平均峰值浓度为80.51微克/毫升。
