Watson T G, Croll N A
Vet Pathol. 1981 Nov;18(6):778-85. doi: 10.1177/030098588101800608.
Cats infected with metacercariae of the fluke Metorchis conjunctus were followed clinically through their infection. Cats given 200 metacercariae showed few symptoms. All the cats passed ova on the 17th day. Three hundred metacercariae caused diarrhea, icterus, discolored urine, green feces and eosinophilia after 18 to 21 days. Eosinophilia, leucine aminopeptidase and alanine aminotransferase were elevated and remain the best indicators for metorchiasis. The hematological and serological abnormalities resolved rapidly and were absent from cats with chronic infection. Acute lesions (less than 32 days) were confined to the biliary trees with extensive epithelial exfoliation, fibrosis, and pus from necrosis, tissue feeding by the worms and pressure atrophy. Chronic infections (32 to 150 days) caused hyperplasia of the bile epithelium, proliferation of connective tissues, and fibrosis of the perilobular areas. Intense eosinophilic infiltrates were replaced by mononuclear cells. Granuloma formation around an ovum was seen in one cat 719 days after infection. Adult worms established preferentially in the left lateral lobe and never in the caudal lobe. No gall bladder involvement was found even in heavy infections.
对感染了吸虫（联胆管吸虫）后尾蚴的猫进行了整个感染过程的临床跟踪。接种200个后尾蚴的猫几乎没有症状。所有猫在第17天排出虫卵。接种300个后尾蚴的猫在18至21天后出现腹泻、黄疸、尿液变色、粪便变绿和嗜酸性粒细胞增多。嗜酸性粒细胞增多、亮氨酸氨肽酶和丙氨酸转氨酶升高，仍然是胆管吸虫病的最佳指标。血液学和血清学异常迅速消退，慢性感染的猫没有这些异常。急性病变（少于32天）局限于胆管，有广泛的上皮脱落、纤维化，以及坏死、虫体取食组织和压迫性萎缩导致的脓液。慢性感染（32至150天）导致胆管上皮增生、结缔组织增生和小叶周围区域纤维化。强烈的嗜酸性粒细胞浸润被单核细胞取代。在一只猫感染719天后，在一个虫卵周围发现了肉芽肿形成。成虫优先定位于左外侧叶，从未在尾叶发现。即使在重度感染中也未发现胆囊受累。
