Edwin E E, Jackman R
Vet Rec. 1981 Jul 25;109(4):75-6. doi: 10.1136/vr.109.4.75.
Values of various alpha-keto acids in whole blood were determined from cases of cerebrocortical necrosis (CCN), a thiamine deficiency disease, and were compared with those from normal animals. Thiamine pyrophosphate is an essential cofactor in the decarboxylation of many alpha-keto acids and this was reflected in elevated values not only of pyruvic acid but of glyoxylic, alpha-keto glutaric, phenyl pyruvic and hydroxyphenyl pyruvic acids in the CCN cases.
从硫胺素缺乏疾病——大脑皮质坏死（CCN）病例中测定了全血中各种α-酮酸的值，并与正常动物的值进行了比较。硫胺素焦磷酸是许多α-酮酸脱羧反应中必不可少的辅因子，这不仅体现在CCN病例中丙酮酸的值升高，还体现在乙醛酸、α-酮戊二酸、苯丙酮酸和对羟基苯丙酮酸的值升高上。
