Moĭseenok A G, Komar V I, Denisova N K, Khil'manovich A P
Vopr Pitan. 1981 Jul-Aug(4):18-22.
The content of free and total pantothenic acid (PA) in the daily urine was studied microbiologically in 55 patients with virus hepatitis. At the height of the disease the excretion of the test vitamin forms with the urine noticeably decreased whatever the disease severity. During reconvalescence PA excretion rose because of the increase diuresis. However, the concentration of the vitamin in the urine did not reach normal. No disorders in PA metabolism were found in patients with hyperbilirubinemia of non-infectious genesis. Unlike normal subjects, oral administration of calcium pantothenate (50 ng) to patients with hepatitis results in a decrease of the excretion of the free form of PA. It is suggested that disorders in PA metabolism in patients with virus hepatitis are manifestations of functional vitamin deficiency which is a consequence of its reduced utilization.
对55例病毒性肝炎患者每日尿液中游离泛酸（PA）和总泛酸的含量进行了微生物学研究。在疾病高峰期，无论病情严重程度如何，检测到的维生素形式随尿液的排泄量均明显减少。在康复期，由于多尿，PA排泄量增加。然而，尿液中维生素的浓度未恢复正常。在非传染性病因的高胆红素血症患者中未发现PA代谢紊乱。与正常受试者不同，对肝炎患者口服泛酸钙（50 ng）会导致PA游离形式的排泄减少。提示病毒性肝炎患者PA代谢紊乱是功能性维生素缺乏的表现，这是其利用率降低的结果。
