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[人类肿瘤中的逆转录病毒D诱导抗原]

[Retrovirus D-induced antigen in human tumors].

作者信息

Kosiakov P N, Pavliuchenkova R P, Kulakova A M, Kosiakova N P

出版信息

Vopr Virusol. 1981 May-Jun(3):324-7.

PMID:7293164
Abstract

Tissues of malignant and benign tumors from 254 patients were examined for the presence in them of a new, retrovirus D-associated antigen. Most frequently, the virus-induced antigen was present in pulmonary carcinomas (54.5%) and in large intestine tumors (25%). This antigen was detected almost with the same frequency (11%-12.5%) in fibroadenomas and mammary carcinomas, only in 8% of gastric tumors and very rarely in fibrous-cystic mastopathies (2.6%). No virus-induced antigen was found in tissues not involved in the cancer process or in tissues of normal subjects. Detection of the retrovirus D-associated antigen in tumor cells indicates the presence in them of this virus or its genome.

摘要

对254例患者的恶性和良性肿瘤组织进行检测,以确定其中是否存在一种新的、与逆转录病毒D相关的抗原。最常见的是,病毒诱导的抗原存在于肺癌(54.5%)和大肠肿瘤(25%)中。在纤维腺瘤和乳腺癌中检测到这种抗原的频率几乎相同(11%-12.5%),仅在8%的胃肿瘤中检测到,在纤维囊性乳腺病中非常罕见(2.6%)。在未参与癌症过程的组织或正常受试者的组织中未发现病毒诱导的抗原。在肿瘤细胞中检测到逆转录病毒D相关抗原表明其中存在这种病毒或其基因组。

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