Lavin J P, Barden T P, Miodovnik M
Am J Obstet Gynecol. 1981 Nov 1;141(5):491-4. doi: 10.1016/s0002-9378(15)33266-x.
Screening for abnormal glucose metabolism was carried out in 2,077 pregnant women. Historical or clinical risk factors for gestational diabetes were present in 959 women (group 1). The remaining 1,118 patients composed group 2. A 50 gm oral glucose load and a 1-hour serum glucose determination with a threshold of 150 mg/dl were used as a glucose challenge screening test (GCT). Patients with an abnormal GCT underwent an oral glucose tolerance test (GTT). Group 1 patients underwent screening at the initial clinic visit or when the clinical risk factor was first recognized, with repeat screening at 28 to 32 weeks if the initial testing was normal. Group 2 patients were screened at 28 to 32 weeks. In group 1, 69 patients (7.2%) exhibited an abnormal GCT and 14 (1.5%) demonstrated an abnormal GTT. In group 2, 68 patients (6.1%) exhibited an abnormal GCT and 16 (1.4%) demonstrated an abnormal GTT. These incidences are not statistically different. The estimated costs per patient screened and per case of gestational diabetes detected were $4.75 and $328.96, respectively.
对2077名孕妇进行了葡萄糖代谢异常筛查。959名女性（第1组）存在妊娠期糖尿病的既往或临床风险因素。其余1118名患者组成第2组。采用50克口服葡萄糖负荷试验及1小时血清葡萄糖测定，阈值为150毫克/分升，作为葡萄糖激发筛查试验（GCT）。GCT异常的患者接受口服葡萄糖耐量试验（GTT）。第1组患者在初次门诊就诊时或首次发现临床风险因素时进行筛查，若初次检测正常，则在孕28至32周时重复筛查。第2组患者在孕28至32周时进行筛查。在第1组中，69名患者（7.2%）GCT异常，14名患者（1.5%）GTT异常。在第2组中，68名患者（6.1%）GCT异常，16名患者（1.4%）GTT异常。这些发生率无统计学差异。筛查每名患者及每例检测出的妊娠期糖尿病的估计成本分别为4.75美元和328.96美元。
