[Pharmacokinetic characteristics of streptomycin and isoniazid administered in ultrasonic aerosols to patients with respiratory organ tuberculosis].

The study on the pharmacokinetics of streptomycin and isoniazid (2012 assays of the concentration) in resected lung tissue and blood specimens from patients with respiratory tuberculosis treated with ultrasound inhalations of the drugs showed that their concentrations in the lungs were high and persisted at the minimum bacteriostatic level for 48 hours. Comparison of the drug levels in the lung tissue with those in the blood revealed correlation between the characteristics. It was most pronounced in 3 and 24 hours (the correlation coefficient ranged within 0.50-0.56). The moderate direct linear relation within the above period allowed one to perform preliminary theoretical estimation of the drug concentrations in the lung tissue using the regression equation and the values of the drug blood levels. The clinical trials (52 cases) showed coincidence of the theoretical estimation with the empirical findings. Therefore, the data of the study are of a practical value and may be used for correction of the therapy with streptomycin and isoniazid ultrasound inhalations, especially when Mycobacterium tuberculosis are resistant to the drugs.