[Basis for the administration of streptomycin and isoniazid in ultrasonic aerosols in the treatment of intrathoracic tuberculosis].

A total of 257 patients with intrathoracic tuberculosis were observed. The levels of streptomycin and isoniazide in the blood and lung tissue (132 resections) were studied comparatively after their administration by different routes (ultrasonic inhalation, per os and intramuscularly) in the doses of 1.0 and 0.6 gm of streptomycin and isoniazide respectively. On the basis of the data of the study it was conlcuded that concentrations of the tuberculostatic agents in the healthy ares of the lung tissue and the walls of the tuberculosis focus were much higher after the drug administration by the routine methods and remained at the minimum bacteriostatic level for 48 hours. Therefore, there is basis for considering administration of streptomycin and isoniazide in the form of ultrasonic aerosols quite justified in treatment of patients with intrathoracic tuberculosis since this administration route provided high levels of the drugs in the disease foci which meets the requirement of local therapy.