Zvenigorodskiĭ V I, Bugaĭchuk Iu D, Kuzovnikova T A, Lukin A A, Zhdanov V G
Antibiotiki. 1981 Sep;26(9):647-51.
The bacitracin production levels in some auxotrophic mutants of a highly active strain 1001 and strain ATCC 10716 were studied. It was shown that auxotrophic mutations in the genomes of the above strains resulted in decreasing of bacitracin production. In double auxotrophic mutants the synthesis of bacitracin was sometimes at the level of the initial strain. It was found that various amino acids and bases added to the cultivation medium in concentrations of 1 to 10 mg/ml either increased or decreased the production of bacitracin. It is suggested that some amino acids may play the decisive role in the control of the bacitracin synthesis.
研究了高活性菌株1001和ATCC 10716的一些营养缺陷型突变体中的杆菌肽生产水平。结果表明，上述菌株基因组中的营养缺陷型突变导致杆菌肽产量下降。在双重营养缺陷型突变体中，杆菌肽的合成有时与初始菌株水平相当。研究发现，向培养基中添加浓度为1至10mg/ml的各种氨基酸和碱基，要么增加要么降低杆菌肽的产量。有人认为，某些氨基酸可能在杆菌肽合成的控制中起决定性作用。
