高产突变地衣芽孢杆菌菌株AL产生杆菌肽：L-亮氨酸的刺激作用

Bacitracin production by the high-yielding mutant Bacillus licheniformis strain AL: stimulatory effect of L-leucine.

作者信息

Haavik H I, Vessia B

出版信息

Acta Pathol Microbiol Scand B. 1978 Apr;86(2):67-70. doi: 10.1111/j.1699-0463.1978.tb00011.x.

DOI:10.1111/j.1699-0463.1978.tb00011.x

Abstract

The high-yielding mutant Bacillus licheniformis AL produced only small amounts of bacitracin in the chemically defined M2 medium. L-leucine markedly stimulated bacitracin production and restored the mutant strain to its place as a superior producer as compared to Bacillus licheniformis ATCC 10716. Leucine also stimulated the growth rate of the mutant. The stimulatory effect of leucine on bacitracin production is discussed in relation to control mechanisms and overproduction of antibiotics.

摘要

高产突变型地衣芽孢杆菌AL在化学成分明确的M2培养基中仅产生少量杆菌肽。与地衣芽孢杆菌ATCC 10716相比，L-亮氨酸显著刺激了杆菌肽的产生，并使突变菌株恢复到其作为优良生产者的地位。亮氨酸还刺激了突变体的生长速率。结合抗生素的控制机制和过量生产，讨论了亮氨酸对杆菌肽生产的刺激作用。