[运用数学实验设计方法优化抗生素妥布霉素生物合成的营养培养基成分]
[Optimization of the nutrient medium composition for the biosynthesis of the antibiotic tobramycin using a mathematical experimental design method].
作者信息
Motkova M O, Korobkova T P, Gladkikh E G
出版信息
Antibiotiki. 1981 Sep;26(9):651-4.
PMID:7294757
Abstract
The mathematical design of the experiment was used for optimization of the nutrient medium for biosynthesis of tobramycin by Streptomyces cremeus var. tobramycini. The use of the orthogonal Latin rectangles provided development of the fermentation medium composition and definition of the optimal concentration of its ingredients. The level of tobramycin production on this medium was 2 times higher than that on the initial one.
摘要
该实验的数学设计用于优化cremeus var. tobramycini链霉菌生物合成妥布霉素的营养培养基。使用正交拉丁矩形可确定发酵培养基的组成并明确其成分的最佳浓度。在这种培养基上妥布霉素的产量水平比初始培养基高出两倍。
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