Hill R, Daunter B, Magon H, Khoo S K, Mackay E V
Aust J Exp Biol Med Sci. 1981 Aug;59(4):469-76. doi: 10.1038/icb.1981.40.
In view of the reported disagreement in the physicochemical properties of ovarian carcinoembryonic antigen (CEA), this study was undertaken to compare the properties of CEA obtained from extracts of ovarian tumour tissue, ascitic fluid and cyst fluid. On the basis of molecular weight estimation and binding properties with Concanavalin A and wheat germ lectin, ovarian CEA from these three sources appeared similar, and also possessed similar properties to those of colonic CEA. On isoelectric focusing, however, it was found that the isoelectric point of CEA from tumour tissue and cyst fluid differed from that from ascitic fluid. It is most likely that this is due to a loss of sialic acid from the CEA released into ascitic fluid.
鉴于有报道称卵巢癌胚抗原（CEA）的物理化学性质存在差异，本研究旨在比较从卵巢肿瘤组织提取物、腹水和囊液中获得的CEA的性质。基于分子量估计以及与伴刀豆球蛋白A和麦胚凝集素的结合特性，来自这三种来源的卵巢CEA似乎相似，并且与结肠CEA也具有相似的性质。然而，在等电聚焦时发现，肿瘤组织和囊液中的CEA的等电点与腹水中的不同。这很可能是由于释放到腹水中的CEA的唾液酸丢失所致。
