Zlateva M, Angelov K
Eksp Med Morfol. 1978;17(4):208-14.
The authors examined morphologic changes in preliminarily damaged and normal myocardium under the influence of hemorrhagic shock. It was established that the preceding damages of the myocardium (microcicatrixes and organizing microinfarctions) made it more sensitive to acute hypoxia under the conditions of hemorrhagic shock. The electrone microscopic and histologic findings in both groups revealed acute and ischemic damages of the myocardium, manifested in vacuolization and distruction of mitochondria, dilatation of sarcoplasmic reticulum, contracted changes and fuxinophilic necrosis. The morfometric determination of the degree of distribution of fuxinophilic necrosis revealed that they were considerably more manifested under the conditions of hemorrhagic shock on the background of myocardiopathy (p less than 0.001).
作者研究了失血性休克影响下初步受损和正常心肌的形态学变化。结果表明，心肌先前的损伤（微瘢痕和正在机化的微梗死）使其在失血性休克条件下对急性缺氧更为敏感。两组的电镜和组织学检查结果均显示心肌存在急性和缺血性损伤，表现为线粒体空泡化和破坏、肌浆网扩张、收缩性改变和嗜酸性坏死。对嗜酸性坏死分布程度的形态计量学测定表明，在心肌病背景下的失血性休克条件下，嗜酸性坏死表现得更为明显（p小于0.001）。
