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[实验性氟哌利多对肺水肿的保护与治疗作用]

[Experimental droperidol protection and treatment of pulmonary edema].

作者信息

Marin I S, Petrov S

出版信息

Eksp Med Morfol. 1978;17(4):221-4.

PMID:729531
Abstract

The authors carried out an experimental study of the protective and therapeutic effect of droperydol on 48 rabbits, with adrenaline lung edema. The results from the conducted studies showed that droperydol, administered both prophylacticaly and therapeuticaly, diminished significantly the gravity of lung edema and increased the percentage of survival up to 67.7% (in rats, treated therapeuticaly) and up to 100% (in the rats, treated prophylacticaly), while the survival did not surpass 20% in the control group. These results were better in comparison with the data, found earlier, indicating the effect of chlorasine, which manifested only protective action in rabbits with lung edema and worsened its course, when it was applied therapeuticaly.

摘要

作者对48只患有肾上腺素性肺水肿的兔子进行了氟哌利多保护和治疗作用的实验研究。研究结果表明,预防性和治疗性给予氟哌利多均能显著减轻肺水肿的严重程度,治疗组大鼠的存活率提高到67.7%,预防组大鼠的存活率提高到100%,而对照组的存活率未超过20%。与之前发现的氯胺酮的数据相比,这些结果更好,氯胺酮在肺水肿兔中仅表现出保护作用,治疗时反而会使病程恶化。

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Eksp Med Morfol. 1978;17(4):221-4.
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