Dodrill C B, Wilkus R J
Epilepsia. 1978 Oct;19(5):453-62. doi: 10.1111/j.1528-1157.1978.tb05172.x.
A broad battery of neuropsychological tests was given to 111 adult epileptics treated primarily with phenytoin. The patients were grouped according to degree of generalized nonepileptiform EEG abnormalities in waking EEGs. In patients classified as None/Mild, Moderate, or Marked in terms of these EEG abnormalities performances on 15 neuropsychological measures were contrasted. Statistically significant differences across the groups were found on 13 of the 15 neuropsychological variables. An orderly decrease in performance occurred as a correlate of an increase in EEG abnormalities. These results were compared to a similar analysis of the correlates of topographic distribution of epileptiform discharges (Absent, Focal, Generalized). It was discovered that degrees of generalized slow wave EEG abnormalities were more potent in differentiating levels of neuropsychological performance than epileptiform discharges. Nevertheless, when discharges and degree of nonepileptiform abnormalities were simultaneously considered, a maximal level of correlation was reached.
对111名主要接受苯妥英治疗的成年癫痫患者进行了一系列广泛的神经心理学测试。根据清醒脑电图中广泛性非癫痫样脑电图异常的程度对患者进行分组。根据这些脑电图异常，将患者分为无/轻度、中度或重度，对比了他们在15项神经心理学测量中的表现。在15项神经心理学变量中的13项上发现了各组之间具有统计学意义的差异。随着脑电图异常的增加，表现出现了有序的下降。将这些结果与对癫痫样放电的地形分布（无、局灶性、广泛性）相关性的类似分析进行了比较。结果发现，广泛性慢波脑电图异常程度在区分神经心理学表现水平方面比癫痫样放电更有效。然而，当同时考虑放电和非癫痫样异常程度时，达到了最大程度的相关性。
