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Preliminary studies of the kinetics of citalopram in man.

作者信息

Overø K F

出版信息

Eur J Clin Pharmacol. 1978 Nov 9;14(1):69-73. doi: 10.1007/BF00560260.

DOI:10.1007/BF00560260
PMID:729609
Abstract

The plasma concentrations of citalopram, a potent serotonin reuptake inhibitor, and its demethylated metabolite have been determined by a specific fluorescence coupling technique during single dose experiments in volunteers and in clinical tests. Citalopram was found to have linear kinetics within the dose range investigated, which were characterized by fairly rapid absorption and slow elimination (biological half-life 1--21/2 days). Steady state levels in the range 120--340 nM (i.e. slightly above those associated with pharmacodynamic activity in animals) were attained within a week. A drug/metabolite ratio of 2--3 was recorded.

摘要

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本文引用的文献

1
Comparison of single dose kinetics of imipramine, nortriptyline and antipyrine in man.
Psychopharmacology (Berl). 1976 Oct 20;50(1):21-7. doi: 10.1007/BF00634149.
2
Neurochemical characterization of a new potent and selective serotonin uptake inhibitor: Lu 10-171.一种新型强效选择性5-羟色胺摄取抑制剂Lu 10 - 171的神经化学特性
Psychopharmacology (Berl). 1977 Mar 16;51(3):225-33. doi: 10.1007/BF00431629.
3
Plasma level monitoring of tricyclic antidepressant therapy.三环类抗抑郁药治疗的血药浓度监测
PharmGKB summary: citalopram pharmacokinetics pathway.
药物基因组学知识库总结：西酞普兰的药代动力学途径。
Pharmacogenet Genomics. 2011 Nov;21(11):769-72. doi: 10.1097/FPC.0b013e328346063f.
4
The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach.蓄意自服过量药物后西酞普兰的群体药代动力学：一种贝叶斯方法。
J Pharmacokinet Pharmacodyn. 2005 Aug;32(3-4):571-605. doi: 10.1007/s10928-005-0022-6.
5
Metabolism and pharmacokinetics of selective serotonin reuptake inhibitors.选择性5-羟色胺再摄取抑制剂的代谢与药代动力学
Cell Mol Neurobiol. 1999 Aug;19(4):443-66. doi: 10.1023/a:1006934807375.
6
Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism.选择性5-羟色胺再摄取抑制剂的临床相关药理学。重点关注药代动力学及对药物氧化代谢影响的综述。
Clin Pharmacokinet. 1997;32 Suppl 1:1-21. doi: 10.2165/00003088-199700321-00003.
7
Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors.选择性5-羟色胺再摄取抑制剂的药代动力学-药效学关系
Clin Pharmacokinet. 1996 Dec;31(6):444-69. doi: 10.2165/00003088-199631060-00004.
8
Citalopram, a selective serotonin reuptake inhibitor: clinical antidepressive and long-term effect--a phase II study.西酞普兰，一种选择性5-羟色胺再摄取抑制剂：临床抗抑郁及长期疗效——一项II期研究
Psychopharmacology (Berl). 1982;77(3):199-204. doi: 10.1007/BF00464566.
9
Comparative animal studies on cardiovascular toxicity of tri- and tetracyclic antidepressants and citalopram; relation to drug plasma levels.三环和四环抗抑郁药及西酞普兰心血管毒性的动物对比研究；与药物血浆水平的关系。
Psychopharmacology (Berl). 1984;82(4):275-81. doi: 10.1007/BF00427669.
10
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Clin Pharmacokinet. 1977 Jul-Aug;2(4):237-51. doi: 10.2165/00003088-197702040-00001.
4
Hepatotoxicity of citalopram in rats and first-pass metabolism.
Arch Toxicol Suppl. 1978(1):177-80. doi: 10.1007/978-3-642-66896-8_25.
5
Effect of a selective 5-HT uptake inhibitor--Lu 10-171--on rat brain 5-HT turnover.一种选择性5-羟色胺摄取抑制剂——Lu 10-171——对大鼠脑5-羟色胺代谢的影响。
Acta Pharmacol Toxicol (Copenh). 1977 Mar;40(3):439-46.
6
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J Pharm Pharmacol. 1976 Jan;28(1):62-4. doi: 10.1111/j.2042-7158.1976.tb04026.x.