Krück F, Bablok W, Besenfelder E, Betzien G, Kaufmann B
Eur J Clin Pharmacol. 1978 Nov 27;14(3):153-61. doi: 10.1007/BF02089953.
Ple 1053 (Azosemid) is a diuretic which resembles furosemide chemically and in its mode of action. When administered intravenously, Ple 1053 was approximately 5 times more potent on a weight basis than furosemide, its dose-response relationship was closer and the slope was steeper. After oral administration Ple 1053 and furosemide were approximately equal in potency. However, the effect of Azosemid in healthy subjects was relatively prolonged and abrupt peaks did not occur.
Ple 1053（阿佐塞米）是一种利尿剂，其化学结构和作用方式与呋塞米相似。静脉注射时，按体重计算，Ple 1053的效力约为呋塞米的5倍，其剂量-反应关系更紧密，斜率更陡。口服后，Ple 1053和呋塞米的效力大致相当。然而，阿佐塞米在健康受试者中的作用相对持久，不会出现突然的峰值。
