Hughson R L, MacFarlane B J
Can J Physiol Pharmacol. 1981 Jun;59(6):567-73. doi: 10.1139/y81-085.
The effect of propranolol on the anaerobic threshold was studied in six healthy male volunteers. The subjects exercised on a cycle ergometer in a progressive exercise test to exhaustion with propranolol or no drug. Power output was increased by 30 W ever 2 min. Propranolol caused a significant reduction of heart rate by 20-45 beats per minute at all power outputs. In light and moderate exercise, no differences in oxygen uptake, ventilation, or blood lactate were observed in the propranolol and no-drug tests. The anaerobic threshold was not different between the no-drug (2.32 +/- 0.19 L O2/min, mean +/J- SD) and the propranolol (2.83 +/- 0.27 L O2/min) test; however, the heart rate at the anaerobic threshold was significantly lower in the propranolol (143 +/- 13 beats per minute) than the no-drug (187 +/- 9 beats per minute) tests. Above the anaerobic threshold, oxygen uptake was similar at a given power output but it reached a lower peak value (p less than 0.02) in the propranolol (3.16 +/- 0.16 L O2/min) versus the no-drug (3.64 +/- 0.39 L O2/min) tests. It was concluded that propranolol caused no change in anaerobic threshold in this specific progressive exercise protocol. The results suggest that a training intensity for endurance exercise bases on the anaerobic threshold does not need to be modified for subjects on propranolol medication.
在六名健康男性志愿者中研究了普萘洛尔对无氧阈值的影响。受试者在递增运动试验中使用自行车测力计进行运动，直至疲劳，试验分为服用普萘洛尔组和未服药组。每2分钟功率输出增加30瓦。在所有功率输出水平下，普萘洛尔使心率显著降低，每分钟降低20 - 45次。在轻度和中度运动中，普萘洛尔试验和未服药试验在摄氧量、通气量或血乳酸方面未观察到差异。未服药试验（2.32±0.19升氧气/分钟，均值±标准差）和普萘洛尔试验（2.83±0.27升氧气/分钟）的无氧阈值无差异；然而，普萘洛尔试验中无氧阈值时的心率（每分钟143±13次）显著低于未服药试验（每分钟187±9次）。在无氧阈值以上，在给定功率输出时摄氧量相似，但普萘洛尔试验（3.16±0.16升氧气/分钟）与未服药试验（3.64±0.39升氧气/分钟）相比，摄氧量达到的峰值较低（p<0.02）。得出的结论是，在这种特定的递增运动方案中，普萘洛尔不会引起无氧阈值的变化。结果表明，对于服用普萘洛尔药物的受试者，基于无氧阈值的耐力运动训练强度无需调整。
