MacFarlane B J, Hughson R L, Green H J, Walters D J, Ranney D A
Can J Physiol Pharmacol. 1983 Sep;61(9):1010-6. doi: 10.1139/y83-151.
The exercise responses to two different progressive, upright cycle ergometer tests were studied in nine healthy, young subjects either with no drug (ND) or following 48 h or oral propranolol (P) (40 mg q.i.d.). The ergometer tests increased work rate by 30 W either every 30 s or every 4 min. Propranolol caused a significant (p less than 0.05) reduction in peak oxygen uptake (VO2) during both the 30-s and 4-min tests (30-s ND, 3949 +/- 718 mL X min-1 (means +/- SD); 30-s P, 3408 +/- 778 mL X min-1; 4-min ND, 4058 +/- 409 mL X min-1; 4-min P, 3725 +/- 573 mL X min-1). There was no difference between 30-s ND and 4-min ND for peak VO2. The ventilatory anaerobic threshold was not significantly different between any test (30-s ND, 2337 +/- 434 mL O2 X min-1; 30-s P, 2174 +/- 406 mL O2 X min-1; ND, 2433 +/- 685 mL O2 X min-1; 4-min P, 2296 +/- 604 mL O2 X min-1). The VO2 at which blood lactate had increased by 0.5 mM above resting levels was significantly lower than the ventilatory anaerobic threshold for the 4-min ND (1917 +/- 489) and the 4-min P (1978 +/- 412) tests, but was not different for the 30-s ND and 30-s P tests. At exhaustion in the progressive tests, the blood PCO2 was higher (p less than 0.05) in both 30-s tests than 4-min tests.(ABSTRACT TRUNCATED AT 250 WORDS)
在9名健康的年轻受试者中，研究了他们在未服用药物（ND）以及服用48小时口服普萘洛尔（P）（40毫克，每日4次）后，对两种不同的递增式直立自行车测力计测试的运动反应。测力计测试每30秒或每4分钟将工作负荷增加30瓦。在30秒和4分钟测试期间，普萘洛尔均导致峰值摄氧量（VO2）显著降低（p<0.05）（30秒ND组，3949±718毫升·分钟-1（平均值±标准差）；30秒P组，3408±778毫升·分钟-1；4分钟ND组，4058±409毫升·分钟-1；4分钟P组，3725±573毫升·分钟-1）。30秒ND组和4分钟ND组的峰值VO2无差异。任何测试之间的通气无氧阈均无显著差异（30秒ND组，2337±434毫升O2·分钟-1；30秒P组，2174±406毫升O2·分钟-1；4分钟ND组，2433±685毫升O2·分钟-1；4分钟P组，2296±604毫升O2·分钟-1）。在4分钟ND组（1917±489）和4分钟P组（1978±412）测试中，血乳酸比静息水平增加0.5毫摩尔时的VO2显著低于通气无氧阈，但在30秒ND组和30秒P组测试中无差异。在递增测试中力竭时，30秒测试的血二氧化碳分压均高于4分钟测试（p<0.05）。（摘要截断于250字）
