Goodlad G A, Clark C M
Cancer Lett. 1981 Oct;14(1):1-5. doi: 10.1016/0304-3835(81)90002-1.
The actin depolymerising activity in plasma, liver and gastrocnemius muscle of normal and tumour-bearing rats and in Walker 256 carcinoma grown in the solid and ascitic form was measured. Similar levels of actin depolymerising activity were observed in solid and ascitic forms of the tumour. No alteration in actin depolymerising activity was found to accompany the increased levels of unpolymerised actin found in the plasma and tissues of the tumour-bearing rat. It was concluded that changes in the state of polymerisation of actin in the tissues of the tumour-bearing host could not be attributed to an effect of the tumour on actin depolymerising activity.
测量了正常大鼠和荷瘤大鼠的血浆、肝脏和腓肠肌以及实体瘤和腹水瘤形式生长的Walker 256癌中的肌动蛋白解聚活性。在实体瘤和腹水瘤形式中观察到相似水平的肌动蛋白解聚活性。在荷瘤大鼠的血浆和组织中未聚合肌动蛋白水平升高的情况下，未发现肌动蛋白解聚活性有改变。得出的结论是，荷瘤宿主组织中肌动蛋白聚合状态的变化不能归因于肿瘤对肌动蛋白解聚活性的影响。
