DeNardo G L, DeNardo S J
Clin Nucl Med. 1981 Oct;6(10S):P37-45. doi: 10.1097/00003072-198110001-00008.
The occurrence of venous thromboembolic disease is of epidemic proportions and clinical manifestations are clearly documented to be neither sensitive nor specific. Whereas contrast venograms are a suitable reference standard, less invasive procedures are necessary for the clinical management of patients. I-125 FUT is currently the preferred procedure for epidemiological studies and measurement of the efficacy of treatment. It is also suitable for documentation of suspected venous thrombosis in the lower leg and calves. Radionuclide venography, when combined with pulmonary scintigraphy, is useful in the definition of venous thromboembolism. In view of the fact that either the pulmonary emboli or the thrombotic origins may be clinically silent, it is particularly attractive when there is a strong suspicion of either one. It may also be used to document venous thrombosis when that condition is suspected on clinical or other grounds except when calf disease is the only clinical manifestation. Despite the limitations of both of these procedures, they correlate remarkably well with the results of contrast venography and are suitable for routine use.
静脉血栓栓塞性疾病的发生率呈流行态势，且临床表现已明确证实既不敏感也不特异。尽管静脉造影是合适的参考标准，但对于患者的临床管理而言，需要侵入性较小的检查方法。I-125纤维蛋白原摄取试验（I-125 FUT）目前是流行病学研究和治疗效果评估的首选方法。它也适用于记录小腿和腓肠肌疑似静脉血栓形成的情况。放射性核素静脉造影与肺闪烁扫描相结合，有助于明确静脉血栓栓塞。鉴于肺栓塞或血栓形成部位在临床上可能无症状，当高度怀疑其中任何一种情况时，这种检查方法尤其具有吸引力。当基于临床或其他原因怀疑存在静脉血栓形成时，除小腿疾病是唯一临床表现外，它也可用于记录静脉血栓形成。尽管这两种检查方法都有局限性，但它们与静脉造影结果的相关性非常好，适合常规使用。
