Düchting W, Vogelsaenger T
Int J Biomed Comput. 1981 Sep;12(5):377-92. doi: 10.1016/0020-7101(81)90050-7.
This paper is concerned with the three-dimensional simulation of tumor growth. For this purpose a cell cycle model of a tumor cell and rules for its multiplication have been developed. Then algorithms and program packages have been constructed describing the spatial and temporal tumor growth. There is a description of several case studies simulating the growth of a single tumor cell in a nutrient medium and a treatment by surgery, radiotherapy and chemotherapy. The simulation results correspond fairly well with the experimentally observed data. As a result it becomes possible to schedule an optimal treatment of tumor diseases by means of computer simulation.
本文关注肿瘤生长的三维模拟。为此，已开发出肿瘤细胞的细胞周期模型及其增殖规则。然后构建了描述肿瘤时空生长的算法和程序包。文中描述了几个案例研究，模拟单个肿瘤细胞在营养培养基中的生长以及通过手术、放疗和化疗进行的治疗。模拟结果与实验观察数据相当吻合。因此，通过计算机模拟来安排肿瘤疾病的最佳治疗方案成为可能。
