Düchting W, Dehl G
J Biomed Eng. 1980 Jul;2(3):167-75. doi: 10.1016/0141-5425(80)90143-0.
In the present paper we attempt to determine the spatial structure and the time behaviour of cell renewal systems, continuing previous studies in which tumor diseases were interpreted as unstable control loops. A computer model wa developed for the two-dimensional cell space, which is described by a set of specifications and growth statements. Selected case studies are then simulated by means of a digital computer (CYBER 76). In the development of this model special emphasis was given to (i) the existence of several cell systems with different mean life spans, growing in competition; (ii) the variability of the mean life spans of a cell and of the initial configuration of cell patterns; (iii) the description of the cell-to-cell interactions; (iv) the perturbation of normal cell growth by tumor cells and their elimination in medicine comparable with a direct irradiation or removal by surgery; (v) the consideration of the loss of tumor cells. The development of this model enables a deeper insight into the structure and function of disturbed cell renewal processes. Systematic studies were made on the influence of the size of a tumor nucleus and the mean life span of a tumor cell on the tumor growth assuming constant cell loss. Furthermore it is possible with this computer model to simulate simple basic cases which are difficult to test in real life.
在本文中，我们试图确定细胞更新系统的空间结构和时间行为，延续之前将肿瘤疾病解释为不稳定控制环的研究。针对二维细胞空间开发了一个计算机模型，该模型由一组规范和生长语句描述。然后通过数字计算机（CYBER 76）对选定的案例研究进行模拟。在这个模型的开发过程中，特别强调了以下几点：（i）存在几个具有不同平均寿命、相互竞争生长的细胞系统；（ii）细胞平均寿命和细胞模式初始构型的可变性；（iii）细胞间相互作用的描述；（iv）肿瘤细胞对正常细胞生长的扰动以及在医学上与直接照射或手术切除相当的对肿瘤细胞的消除；（v）对肿瘤细胞损失的考虑。这个模型的开发能够更深入地洞察受干扰的细胞更新过程的结构和功能。在假设细胞损失恒定的情况下，对肿瘤核大小和肿瘤细胞平均寿命对肿瘤生长的影响进行了系统研究。此外，利用这个计算机模型可以模拟在现实生活中难以测试的简单基本情况。
