C反应蛋白对小鼠肺炎链球菌感染具有保护作用。
C-reactive protein is protective against Streptococcus pneumoniae infection in mice.
作者信息
Mold C, Nakayama S, Holzer T J, Gewurz H, Du Clos T W
出版信息
J Exp Med. 1981 Nov 1;154(5):1703-8. doi: 10.1084/jem.154.5.1703.
Abstract
C-reactive protein (CRP) has several properties that suggest that it may function as a bacterial opsonin. CRP shows binding reactivity with pneumococcal C-polysaccharide, the cell wall carbohydrate of Streptococcus pneumoniae. In this study we have demonstrated protection of mice against serotypes 3 and 4 of S. pneumoniae infection by a single prior injection of CRP. This effect was seen both in mice that lacked antibody to phosphocholine and in normal mice. Thus the opsonic properties of CRP previously described may be related to protection against pneumococcal infection.
摘要
C反应蛋白（CRP）具有多种特性，表明它可能作为一种细菌调理素发挥作用。CRP与肺炎球菌C多糖（肺炎链球菌的细胞壁碳水化合物）表现出结合反应性。在本研究中，我们已经证明，预先单次注射CRP可保护小鼠免受肺炎链球菌3型和4型感染。在缺乏抗磷酸胆碱抗体的小鼠和正常小鼠中均观察到这种效应。因此，先前描述的CRP的调理特性可能与预防肺炎球菌感染有关。
相似文献
1
C-reactive protein is protective against Streptococcus pneumoniae infection in mice.C反应蛋白对小鼠肺炎链球菌感染具有保护作用。
J Exp Med. 1981 Nov 1;154(5):1703-8. doi: 10.1084/jem.154.5.1703.
2
Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors.C反应蛋白和天然抗体对肺炎链球菌感染的保护作用需要补体，但不需要Fcγ受体。
J Immunol. 2002 Jun 15;168(12):6375-81. doi: 10.4049/jimmunol.168.12.6375.
3
Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide.人C反应蛋白可保护小鼠免受肺炎链球菌感染，且不与肺炎球菌C多糖结合。
J Immunol. 2007 Jan 15;178(2):1158-1163. doi: 10.4049/jimmunol.178.2.1158.
4
5
Correlation of serum opsonins with in vitro phagocytosis of Streptococcus pneumoniae.血清调理素与肺炎链球菌体外吞噬作用的相关性
Infect Immun. 1985 Oct;50(1):213-7. doi: 10.1128/iai.50.1.213-217.1985.
6
Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types.磷胆碱结合抗体赋予小鼠抗肺炎球菌感染的能力：磷胆碱结合的特异性及其与多种类型的关系。
Infect Immun. 1983 Feb;39(2):993-9. doi: 10.1128/iai.39.2.993-999.1983.
7
The role of the spleen in the protective effect of C-reactive protein in Streptococcus pneumoniae infection.脾脏在C反应蛋白对肺炎链球菌感染的保护作用中的角色。
Clin Exp Immunol. 1983 Nov;54(2):319-26.
8
The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection.C 反应蛋白上的磷酸胆碱结合口袋对于最初保护小鼠免受肺炎球菌感染是必要的。
J Biol Chem. 2012 Dec 14;287(51):43116-25. doi: 10.1074/jbc.M112.427310. Epub 2012 Nov 8.
9
Anti-polysaccharide immunoglobulin isotype levels and opsonic activity of antisera: relationships with protection against Streptococcus pneumoniae infection in mice.
J Infect Dis. 1995 Aug;172(2):562-5. doi: 10.1093/infdis/172.2.562.
10
[Inhibitory effect of human C-reactive protein (CRP) on the antibody response in mice to pneumococcal C-polysaccharide].
Nihon Saikingaku Zasshi. 1984 Sep;39(5):809-15. doi: 10.3412/jsb.39.809.
引用本文的文献
1
Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface.对肺炎球菌长期感染的防护涉及C反应蛋白的结构变化以及随后与细菌表面的磷酸胆碱和淀粉样蛋白的结合。
Front Immunol. 2025 Jul 16;16:1631409. doi: 10.3389/fimmu.2025.1631409. eCollection 2025.
2
Severe COVID-19 disease is associated with genetic factors affecting plasma ACE2 receptor and CRP concentrations.重症 COVID-19 疾病与影响血浆 ACE2 受体和 CRP 浓度的遗传因素有关。
Sci Rep. 2025 Feb 8;15(1):4708. doi: 10.1038/s41598-025-89306-4.
3
Extra-pulmonary control of respiratory defense.肺外对呼吸防御的控制。
Cell Immunol. 2024 Jul-Aug;401-402:104841. doi: 10.1016/j.cellimm.2024.104841. Epub 2024 Jun 7.
4
Soluble Human Lectins at the Host-Microbe Interface.宿主-微生物界面上的可溶性人源凝集素。
Annu Rev Biochem. 2024 Aug;93(1):565-601. doi: 10.1146/annurev-biochem-062917-012322. Epub 2024 Jul 2.
5
A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects.C-反应蛋白（CRP）作为炎症和免疫反应介质的生物功能综述：区分五聚体和修饰型 CRP 同工型的作用。
Front Immunol. 2023 Sep 15;14:1264383. doi: 10.3389/fimmu.2023.1264383. eCollection 2023.
6
C-reactive protein - My perspective on its first half century, 1930-1982.C-反应蛋白——我对其前半个世纪（1930-1982 年）的看法。
Front Immunol. 2023 Mar 2;14:1150103. doi: 10.3389/fimmu.2023.1150103. eCollection 2023.
7
Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish.斑马鱼中肺炎链球菌感染的固有免疫反应特征。
PLoS Genet. 2023 Jan 9;19(1):e1010586. doi: 10.1371/journal.pgen.1010586. eCollection 2023 Jan.
8
C-Reactive Protein Controls IL-23 Production by Human Monocytes.C 反应蛋白通过人单核细胞控制白细胞介素-23 的产生。
Int J Mol Sci. 2021 Oct 28;22(21):11638. doi: 10.3390/ijms222111638.
9
A Single-Center Retrospective Observational Study Evaluating the Favorable Predictive Factors for the Disease Control Time of Treatment with Tocilizumab in Patients of Rheumatoid Arthritis.一项单中心回顾性观察研究：评估类风湿关节炎患者使用托珠单抗治疗疾病控制时间的有利预测因素
J Inflamm Res. 2021 Aug 5;14:3721-3728. doi: 10.2147/JIR.S323577. eCollection 2021.
10
The Effect of Tocilizumab on Inflammatory Markers in Patients Hospitalized with Serious Infections. Case Series and Review of Literature.托珠单抗对因严重感染住院患者炎症标志物的影响。病例系列及文献综述。
Life (Basel). 2021 Mar 20;11(3):258. doi: 10.3390/life11030258.
本文引用的文献
1
THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD : I. DISTRIBUTION OF THE REACTIVE PROTEIN IN PATIENTS' SERA AND THE EFFECT OF CALCIUM ON THE FLOCCULATION REACTION WITH C POLYSACCHARIDE OF PNEUMOCOCCUS.急性感染时正常血液中不存在的蛋白质的出现：I. 患者血清中反应蛋白的分布及钙离子对与肺炎球菌 C 多糖的絮凝反应的影响。
J Exp Med. 1941 Jan 31;73(2):173-82. doi: 10.1084/jem.73.2.173.
2
The chemical composition of pneumococcal C-polysaccharide.肺炎球菌C多糖的化学成分。
J Biol Chem. 1963 Jun;238:1928-34.
3
In vitro effects of C-reactive protein on phagocytosis.C反应蛋白对吞噬作用的体外效应。
J Bacteriol. 1962 May;83(5):1017-24. doi: 10.1128/jb.83.5.1017-1024.1962.
4
Interaction of C-reactive protein with liposomes. III. Membrane requirements for binding.C反应蛋白与脂质体的相互作用。III. 结合的膜要求。
J Immunol. 1981 Mar;126(3):856-60.
5
Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.在正常小鼠血清中发现的抗磷酸胆碱抗体可预防3型肺炎链球菌的静脉感染。
J Exp Med. 1981 Mar 1;153(3):694-705. doi: 10.1084/jem.153.3.694.
6
The role of the spleen in experimental pneumococcal bacteremia.脾脏在实验性肺炎球菌菌血症中的作用。
J Clin Invest. 1981 Apr;67(4):975-82. doi: 10.1172/jci110148.
7
Mouse C-reactive protein and endotoxin-induced resistance.小鼠C反应蛋白与内毒素诱导的抗性。
J Bacteriol. 1965 Dec;90(6):1520-4. doi: 10.1128/jb.90.6.1520-1524.1965.
8
Affinity labeling of a phosphorylcholine binding mouse myeloma protein.磷酸胆碱结合小鼠骨髓瘤蛋白的亲和标记
Biochemistry. 1972 Feb 29;11(5):766-71. doi: 10.1021/bi00755a014.
9
Stimulating effect of C-reactive protein on phagocytosis of various species of pathogenic bacteria.C反应蛋白对多种病原菌吞噬作用的刺激效应。
Clin Exp Immunol. 1971 Jun;8(6):941-8.
10
Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide.C反应蛋白对肺炎球菌C多糖胆碱磷酸残基的特异性。
Proc Soc Exp Biol Med. 1971 Feb;136(2):612-4. doi: 10.3181/00379727-136-35323.
Zotero 插件