Mold C, Nakayama S, Holzer T J, Gewurz H, Du Clos T W
J Exp Med. 1981 Nov 1;154(5):1703-8. doi: 10.1084/jem.154.5.1703.
C-reactive protein (CRP) has several properties that suggest that it may function as a bacterial opsonin. CRP shows binding reactivity with pneumococcal C-polysaccharide, the cell wall carbohydrate of Streptococcus pneumoniae. In this study we have demonstrated protection of mice against serotypes 3 and 4 of S. pneumoniae infection by a single prior injection of CRP. This effect was seen both in mice that lacked antibody to phosphocholine and in normal mice. Thus the opsonic properties of CRP previously described may be related to protection against pneumococcal infection.
C反应蛋白（CRP）具有多种特性，表明它可能作为一种细菌调理素发挥作用。CRP与肺炎球菌C多糖（肺炎链球菌的细胞壁碳水化合物）表现出结合反应性。在本研究中，我们已经证明，预先单次注射CRP可保护小鼠免受肺炎链球菌3型和4型感染。在缺乏抗磷酸胆碱抗体的小鼠和正常小鼠中均观察到这种效应。因此，先前描述的CRP的调理特性可能与预防肺炎球菌感染有关。
