小鼠C反应蛋白与内毒素诱导的抗性。
Mouse C-reactive protein and endotoxin-induced resistance.
作者信息
Patterson L T, Higginbotham R D
出版信息
J Bacteriol. 1965 Dec;90(6):1520-4. doi: 10.1128/jb.90.6.1520-1524.1965.
Abstract
Patterson, L. T. (University of Texas, Galveston), and R. D. Higginbotham. Mouse C-reactive protein and endotoxin-induced resistance. J. Bacteriol. 90:1520-1524. 1965.-The relationship between the level of C-reactive protein (CRP) in the sera of mice and resistance to Staphylococcus aureus infection after the injection of Escherichia coli endotoxin was studied. The CRP level was essentially unchanged at 6 hr after endotoxin, and resistance was slightly decreased. At 24 hr after endotoxin, both CRP levels and resistance were increased. Since the increase in the CRP level and resistance appeared to be associated, it was of interest that, when mouse CRP was tested for in vitro reactions with several strains of bacteria, cells of all species of gram-positive bacteria tested (including S. aureus) were agglutinated by CRP. E. coli was not agglutinated under the conditions of the test. It is proposed that mouse CRP is an opsonin, and possibly a lysin, and is involved in nonspecific resistance to infection with S. aureus.
摘要
帕特森，L.T.（得克萨斯大学加尔维斯顿分校）和R.D.希金博特姆。小鼠C反应蛋白与内毒素诱导的抵抗力。《细菌学杂志》90:1520 - 1524。1965年。——研究了小鼠血清中C反应蛋白（CRP）水平与注射大肠杆菌内毒素后对金黄色葡萄球菌感染的抵抗力之间的关系。内毒素注射后6小时，CRP水平基本未变，抵抗力略有下降。内毒素注射后24小时，CRP水平和抵抗力均升高。由于CRP水平的升高和抵抗力的增加似乎相关，有趣的是，当测试小鼠CRP与几种细菌菌株的体外反应时，所有测试的革兰氏阳性菌（包括金黄色葡萄球菌）的细胞都被CRP凝集。在测试条件下，大肠杆菌未被凝集。有人提出小鼠CRP是一种调理素，可能还是一种溶素，并且参与对金黄色葡萄球菌感染的非特异性抵抗力。
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