Akaho E, Iga K, Kraal J, Hussain A
J Pharm Sci. 1981 Nov;70(11):1225-8. doi: 10.1002/jps.2600701111.
Interactions of phenolic compounds 4-hexylresorcinol and 3,4-dimethylphenol with esters were studied using hexane-ester cosolvent systems by both phase solubility and partitioning methods. The data obtained by the phase solubility method were variable and could not be analyzed by any mathematical model. The data obtained by the partitioning method, however, strongly suggest that 4-hexylresorcinol forms 1:1 and 1:2 complexes with the esters in hexane, while 3,4-dimethylphenol forms only 1:1 complexes with the same esters.
使用正己烷 - 酯类共溶剂体系，通过相溶解度法和分配法研究了酚类化合物4 - 己基间苯二酚和3,4 - 二甲基苯酚与酯类的相互作用。通过相溶解度法获得的数据具有变异性，无法用任何数学模型进行分析。然而，通过分配法获得的数据强烈表明，4 - 己基间苯二酚在正己烷中与酯类形成1:1和1:2的络合物，而3,4 - 二甲基苯酚与相同的酯类仅形成1:1的络合物。
