Iga K, Hussain A, Kashihara T
J Pharm Sci. 1981 Aug;70(8):939-43. doi: 10.1002/jps.2600700828.
The effect of ethyl myristate on the release rate of 4-hexylresorcinol from petrolatum base was studied at pH 7.4 and 37 degrees. 4-Hexylresorcinol was analyzed spectrophotometrically at 278 nm. The release rate of hexylresorcinol from the ointments was directly proportional to the square root of time and depended on the percentage of ethyl myristate in the ointment base. For 0, 0.5, 1, 3, and 5% of ethyl myristate, the release rates were 29.6, 35.4, 38.3, 55.7, and 70.0 micrograms/hr1/2/cm2, respectively. The solubility of hexylresorcinol in the petrolatum base was determined as a function of ethyl myristate using partitioning techniques. The enhancement in hexylresorcinol solubility was rationalized on the basis of 1:1 and 1:2 complexes between hexylresorcinol and ethyl myristate. The complexation constants of these complexes were estimated to be 10 M-1 and 206.1 M-2, respectively. The diffusion coefficient of hexylresorcinol in the petrolatum base was estimated to be 1.31 x 10(-8) cm2/sec.
在pH值为7.4和37摄氏度的条件下，研究了肉豆蔻酸乙酯对4 - 己基间苯二酚从凡士林基质中释放速率的影响。通过分光光度法在278nm波长下分析4 - 己基间苯二酚。己基间苯二酚从软膏中的释放速率与时间的平方根成正比，并取决于软膏基质中肉豆蔻酸乙酯的百分比。对于肉豆蔻酸乙酯含量为0%、0.5%、1%、3%和5%的情况，释放速率分别为29.6、35.4、38.3、55.7和70.0微克/小时1/2/平方厘米。使用分配技术测定了己基间苯二酚在凡士林基质中的溶解度与肉豆蔻酸乙酯含量的函数关系。基于己基间苯二酚与肉豆蔻酸乙酯之间的1:1和1:2络合物，合理解释了己基间苯二酚溶解度的增强。这些络合物的络合常数估计分别为10 M-1和206.1 M-2。己基间苯二酚在凡士林基质中的扩散系数估计为1.31×10(-8)平方厘米/秒。
